The centrosome in neuronal development

被引：164

作者：

Higginbotham, Holden R. ^{[1
]}

Gleeson, Joseph G. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Neurosci, Biomed Sci Grad Program, La Jolla, CA 92093 USA

来源：

TRENDS IN NEUROSCIENCES | 2007年 / 30卷 / 06期

关键词：

CEREBELLAR GRANULE NEURONS; ASYMMETRIC CELL-DIVISION; ADENOMATOUS POLYPOSIS-COLI; DIRECTIONAL GUIDANCE; NEURAL PRECURSORS; MOLECULAR CONTROL; NUCLEAR-MOVEMENT; CEREBRAL-CORTEX; BETA-CATENIN; IN-VITRO;

D O I：

10.1016/j.tins.2007.04.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Establishment of polarity is an essential process during proliferation, migration and differentiation in neurons, and the signaling pathways leading to polarization of the cytoskeleton are topics of intense research. One key marker for cell polarity is the centrosome, also known as the microtubule-organizing center. Recent discoveries have shown that the position of the centrosome is precisely regulated during neurogenesis, migration and differentiation, leading to the segregation of cell fate factors, efficient nucleokinesis and directed neurite outgrowth, respectively. Here, we review recent advances in the understanding of this interesting organelle and propose a model whereby centrosome position, determined by extracellular factors, directs multiple aspects of neuronal development.

引用

页码：276 / 283

页数：8

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