Optimizing pyramided transgenic Bt crops for sustainable pest management

被引:277
作者
Carriere, Yves [1 ]
Crickmore, Neil [2 ]
Tabashnik, Bruce E. [1 ]
机构
[1] Univ Arizona, Dept Entomol, Tucson, AZ 85721 USA
[2] Univ Sussex, Sch Life Sci, Brighton, E Sussex, England
关键词
BACILLUS-THURINGIENSIS TOXINS; EUROPEAN CORN-BORER; HELICOVERPA-ZEA LEPIDOPTERA; FIELD-DERIVED STRAIN; INSECT RESISTANCE; TOLERANCE RESPONSE; CROSS-RESISTANCE; MULTIPLE TOXINS; FITNESS COSTS; CRY1AB TOXIN;
D O I
10.1038/nbt.3099
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Transgenic crop pyramids producing two Or more Bacillus thuringiensis (Bt) toxins that kill the same insect pest have been widely used to delay evolution of pest resistance. To assess the potential of pyramids to achieve this goal, we analyze data from 38 studies that report effects of ten Bt toxins used in transgenic crops against 15 insect pests. We find that compared with optimal low levels of insect survival, survival on currently used pyramids is often higher for both susceptible insects and insects resistant to one of the toxins in the pyramid. Furthermore, we find that cross-resistance and antagonism between toxins used in pyramids are common, and that these problems are associated with the similarity of the amino acid sequences of domains II and III of the toxins, respectively. This analysis should assist in future pyramid design and the development of sustainable resistance management strategies.
引用
收藏
页码:161 / 168
页数:8
相关论文
共 78 条
[1]  
Adamczyk JJ, 2004, FLA ENTOMOL, V87, P427, DOI 10.1653/0015-4040(2004)087[0427:LAFPOC]2.0.CO
[2]  
2
[3]  
Ali MI, 2007, J ECON ENTOMOL, V100, P921, DOI 10.1603/0022-0493(2007)100[921:SOBATB]2.0.CO
[4]  
2
[5]   Proportions of different habitat types are critical to the fate of a resistance allele [J].
Alphey, Nina ;
Coleman, Paul G. ;
Bonsall, Michael B. ;
Alphey, Luke .
THEORETICAL ECOLOGY, 2008, 1 (02) :103-115
[6]   Scant evidence supports EPA's pyramided Bt corn refuge size of 5% [J].
Alyokhin, Andrei .
NATURE BIOTECHNOLOGY, 2011, 29 (07) :577-578
[7]   Vip3Aa Tolerance Response of Helicoverpa armigera Populations From a Cry1Ac Cotton Planting Region [J].
An, Jingjie ;
Gao, Yulin ;
Wu, Kongming ;
Gould, Fred ;
Gao, Jianhua ;
Shen, Zhicheng ;
Lei, Chaoliang .
JOURNAL OF ECONOMIC ENTOMOLOGY, 2010, 103 (06) :2169-2173
[8]  
[Anonymous], 1998, ENV PROT AG WHIT PAP
[9]  
[Anonymous], 2007, PEST NEWS STOR EPA A
[10]   Evolution of Bacillus thuringiensis Cry toxins insecticidal activity [J].
Bravo, Alejandra ;
Gomez, Isabel ;
Porta, Helena ;
Ines Garcia-Gomez, Blanca ;
Rodriguez-Almazan, Claudia ;
Pardo, Liliana ;
Soberon, Mario .
MICROBIAL BIOTECHNOLOGY, 2013, 6 (01) :17-26