Novel synthesis of 2′-O-methylguanosine

被引：22

作者：

Chow, S

Wen, K

Sanghvi, YS

Theodorakis, EA

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

[2] ISIS Pharmaceut Inc, Carlsbad Res Ctr, Carlsbad, CA 92008 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(03)00291-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An efficient and chemoselective synthesis of 2'-O-methylguanosine (6) has been accomplished in high yield without protection of the guanine base. The salient feature of the synthesis of 6 lies in the application of methylene-bis-(diisopropylsilyl chloride), (MDPSCl2, 2) as a new 3',5'-O-protecting group for nucleosides. Use of CH3Cl as a weak electrophile and NaHMDS as a mild base was crucial to the success of the 2'-O-methylation of 3',5'-O-protected guanosine. (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：1631 / 1634

页数：4

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