SWItching off methylated DNA

被引：6

作者：

Wade, PA ^{[1
]}

机构：

[1] NIEHS, Mol Carcinogenesis Lab, Res Triangle Pk, NC 27709 USA

来源：

NATURE GENETICS | 2005年 / 37卷 / 03期

关键词：

D O I：

10.1038/ng0305-212

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The mechanism by which cytosine methylation stably represses transcription is of great interest. A new study provides evidence associating DNA methylation, MeCP2 and the SWI/SNF chromatin-remodeling factor, implicating local chromatin architecture in DNA methylation-dependent transcriptional repression.

引用

页码：212 / 213

页数：3

共 8 条

[1] The DNA methyltransferases of mammals [J].

Bestor, TH .

HUMAN MOLECULAR GENETICS, 2000, 9 (16) :2395-2402

[2] Methylation-induced repression - Belts, braces, and chromatin [J].

Bird, AP ;

Wolffe, AP .

CELL, 1999, 99 (05) :451-454

[3] The methyl-CpG binding transcriptional repressor MeCP2 stably associates with nucleosomal DNA [J].

Chandler, SP ;

Guschin, D ;

Landsberger, N ;

Wolffe, AP .

BIOCHEMISTRY, 1999, 38 (22) :7008-7018

[4]

JONES SC, 1991, SOCIOBIOLOGY, V19, P187

[5] Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex [J].

Nan, XS ;

Ng, HH ;

Johnson, CA ;

Laherty, CD ;

Turner, BM ;

Eisenman, RN ;

Bird, A .

NATURE, 1998, 393 (6683) :386-389

[6] Cooperation between complexes that regulate chromatin structure and transcription [J].

Narlikar, GJ ;

Fan, HY ;

Kingston, RE .

CELL, 2002, 108 (04) :475-487

[7] Solution structure of the methyl-CpG binding domain of human MBD1 in complex with methylated DNA [J].

Ohki, I ;

Shimotake, N ;

Fujita, N ;

Jee, JG ;

Ikegami, T ;

Nakao, M ;

Shirakawa, M .

CELL, 2001, 105 (04) :487-497

[8]

2005, NAT GENET, V37, P254

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