Synthesis, biological evaluation and DNA binding properties of novel mono and bisnaphthalimides

被引：72

作者：

Braña, MF

Cacho, M

Ramos, A

Domínguez, MT

Pozuelo, JM

Abradelo, C

Rey-Stolle, MF

Yuste, M

Carrasco, C

Bailly, C

机构：

[1] Univ San Pablo CEU, Fac CC Expt & Salud, Dept CC Quim, Madrid 28668, Spain

[2] Univ San Pablo CEU, Fac CC Expt & Salud, Dept Biol Celular Bioquim & Biol Mol, Madrid 28668, Spain

[3] Univ San Pablo CEU, Fac CC Expt & Salud, Dept Matemat Fis Aplicada & Fisicoquim, Madrid 28668, Spain

[4] INSERM, U524, F-59045 Lille, France

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2003年 / 1卷 / 04期

关键词：

D O I：

10.1039/b209042b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel series of mono and bisnaphthalimides was synthesized and their antiproliferative activities were evaluated against three tumor cell lines. Bisnaphthalimides 3 and 4, bearing a pyrazine ring fused to the naphthalimide system, showed activities in the order of 10(-8) muM, similar to elinafide. DNA binding properties and the ability to induce DNA damage were studied for some of the most active compounds.

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收藏

页码：648 / 654

页数：7

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