Clinical importance of HLA-DPB1 in haematopoietic cell transplantation

被引：18

作者：

Shaw, B. E.

Gooley, T.

Madrigal, J. A.

Malkki, M.

Marsh, S. G. E.

Petersdorf, E. W.

机构：

[1] Royal Free Hosp, Anthony Nolan Res Inst, London NW3 2QG, England

[2] City Hosp Nottingham, Dept Haematol, Nottingham, England

[3] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA

来源：

TISSUE ANTIGENS | 2007年 / 69卷

关键词：

HCT; HLA-DPBI; unrelated donor; SURVIVAL;

D O I：

10.1111/j.1399-0039.2006.759_4.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

There is increasing evidence for a significant effect of human leukocyte antigen (HLA)-DPB1 mismatching on complications following unrelated donor haematopoietic cell transplantation (HCT). In this analysis of 5930 patient/donor pairs, we found that a DPB1 mismatch predicted significantly for an increased risk of acute graft-vs-host disease [hazard ratio (HR): 1.33; P-value = < 0.0001], while protecting against disease relapse (HR: 0.82, P-value = 0.01). These data support an immunogenic role for HLA-DPB1 in HCT and the need for pretransplant tissue typing at this locus.

引用

收藏

页码：36 / 41

页数：6

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