Transforming growth factor-β and microRNA:mRNA regulatory networks in epithelial plasticity

被引：129

作者：

Zavadil, Jiri

Narasimhan, Manisha

Blumenberg, Miroslav

Schneider, Robert J.

机构：

[1] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA

[2] NYU, Sch Med, NYU Canc Inst, New York, NY 10016 USA

[3] NYU, Sch Med, Dept Microbiol, New York, NY 10016 USA

[4] NYU, Sch Med, Dept Dermatol, New York, NY 10016 USA

来源：

CELLS TISSUES ORGANS | 2007年 / 185卷 / 1-3期

关键词：

microRNAs; gene expression regulation; transforming growth factor-beta 1; epithelial-mesenchymal transition; neoplasms;

D O I：

10.1159/000101316

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Noncoding microRNAs act as posttranscriptional repressors of gene function and are often deregulated in cancers and other diseases. Here we review recent findings on microRNA roles in tumorigenesis and report a microRNA profiling screen in transforming growth factor-beta 1 (TGF-beta)-induced epithelial-mesenchymal transition (EMT) in human keratinocytes, a model of epithelial cell plasticity underlying epidermal injury and skin carcinogenesis. We describe a novel EMT-specific microRNA signature that includes induction of miR-21, a candidate oncogenic microRNA associated with carcinogenesis. By integrating the microRNA screen results with target prediction algorithms and gene expression profiling data, we outline a framework for TGF-beta-directed microRNA: messenger RNA (mRNA) regulatory circuitry and discuss its biological relevance for tumor progression. Copyright (c) 2007 S. Karger AG, Basel.

引用

页码：157 / 161

页数：5

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