Pain pharmacology in migraine: focus on CGRP and CGRP receptors

被引:24
作者
Benemei, S.
Nicoletti, P.
Capone, J. A.
Geppetti, P. [1 ]
机构
[1] Univ Florence, Dept Crit Care Med & Surg, Clin Pharmacol Unit, I-50121 Florence, Italy
[2] Azienda Univ Osped S Anna, Dept Neurosci, Headache Ctr, Ferrara, Italy
关键词
calcitonin gene-related peptide; neurogenic vasodilatation; migraine; receptor antagonist; meninges;
D O I
10.1007/s10072-007-0757-5
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Over the last 100 years, the discovery of new analgesics has been a complex and difficult task. However, remarkable progress in the identification of novel molecular targets relevant for pain medicines has been reported. Here we will focus on the neuropeptide calcitonin gene-related peptide (CGRP) and its receptors (CGRP-R) because of their role in migraine mechanism and migraine therapy. Recent preclinical and clinical data on the localisation, regulation and plasma levels of CGRP and on the function of CGRP-R will be summarised. The reviewed findings highlight the major function of CGRP in migraine and the use of CGRP-R antagonists as a novel approach for the treatment of migraine attack and, perhaps, as migraine prophylactic medicines.
引用
收藏
页码:S89 / S93
页数:5
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