共 39 条
Pain pharmacology in migraine: focus on CGRP and CGRP receptors
被引:24
作者:

Benemei, S.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florence, Dept Crit Care Med & Surg, Clin Pharmacol Unit, I-50121 Florence, Italy

Nicoletti, P.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florence, Dept Crit Care Med & Surg, Clin Pharmacol Unit, I-50121 Florence, Italy

Capone, J. A.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florence, Dept Crit Care Med & Surg, Clin Pharmacol Unit, I-50121 Florence, Italy

Geppetti, P.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Florence, Dept Crit Care Med & Surg, Clin Pharmacol Unit, I-50121 Florence, Italy Univ Florence, Dept Crit Care Med & Surg, Clin Pharmacol Unit, I-50121 Florence, Italy
机构:
[1] Univ Florence, Dept Crit Care Med & Surg, Clin Pharmacol Unit, I-50121 Florence, Italy
[2] Azienda Univ Osped S Anna, Dept Neurosci, Headache Ctr, Ferrara, Italy
关键词:
calcitonin gene-related peptide;
neurogenic vasodilatation;
migraine;
receptor antagonist;
meninges;
D O I:
10.1007/s10072-007-0757-5
中图分类号:
R74 [神经病学与精神病学];
学科分类号:
摘要:
Over the last 100 years, the discovery of new analgesics has been a complex and difficult task. However, remarkable progress in the identification of novel molecular targets relevant for pain medicines has been reported. Here we will focus on the neuropeptide calcitonin gene-related peptide (CGRP) and its receptors (CGRP-R) because of their role in migraine mechanism and migraine therapy. Recent preclinical and clinical data on the localisation, regulation and plasma levels of CGRP and on the function of CGRP-R will be summarised. The reviewed findings highlight the major function of CGRP in migraine and the use of CGRP-R antagonists as a novel approach for the treatment of migraine attack and, perhaps, as migraine prophylactic medicines.
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页码:S89 / S93
页数:5
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