Phagocytosis imprints heterogeneity in tissue-resident macrophages

被引：224

作者：

A-Gonzalez, Noelia ^{[1
]}

Quintana, Juan A. ^{[1
]}

Garcia-Silva, Susana ^{[3
]}

Mazariegos, Marina ^{[3
]}

Gonzalez de la Aleja, Arturo ^{[1
]}

Nicolas-Avila, Jose A. ^{[1
]}

Walter, Wencke ^{[2
]}

Adrover, Jose M. ^{[1
]}

Crainiciuc, Georgiana ^{[1
]}

Kuchroo, Vijay K. ^{[4
]}

Rothlin, Carla V. ^{[5
]}

Peinado, Hector ^{[3
]}

Castrillo, Antonio ^{[6
]}

Ricote, Mercedes ^{[2
]}

Hidalgo, Andres ^{[1
,7
]}

机构：

[1] Ctr Nacl Invest Cardiovasc Carlos III, Area Cell & Dev Biol, Madrid 28029, Spain

[2] Ctr Nacl Invest Cardiovasc Carlos III, Area Myocardial Pathophysiol, Madrid 28029, Spain

[3] Spanish Natl Canc Res Ctr, Mol Oncol Program, Microenvironm & Metastasis Grp, Madrid 28029, Spain

[4] Brigham & Womens Hosp, Evergrande Ctr Immunol Dis, Boston, MA 02115 USA

[5] Yale Sch Med, Immunobiol Dept, New Haven, CT 06510 USA

[6] Univ Las Palmas Gran Canaria, Inst Univ Invest Biomed & Sanitarias, CSIC Madrid, Inst Invest Biomed Alberto Sols,Unidad Asociada, Las Palmas Gran Canaria 35001, Spain

[7] Ludwig Maximilians Univ Munchen, Inst Cardiovasc Prevent, D-80539 Munich, Germany

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2017年 / 214卷 / 05期

基金：

美国国家卫生研究院;

关键词：

ACTIVATED RECEPTOR-GAMMA; APOPTOTIC CELLS; GENE-EXPRESSION; EPITHELIAL-CELLS; PPAR-GAMMA; TGF-BETA; CLEARANCE; ENGULFMENT; INDUCTION; DIFFERENTIATION;

D O I：

10.1084/jem.20161375

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Tissue-resident macrophages display varying phenotypic and functional properties that are largely specified by their local environment. One of these functions, phagocytosis, mediates the natural disposal of billions of cells, but its mechanisms and consequences within living tissues are poorly defined. Using a parabiosis-based strategy, we identified and isolated macrophages from multiple tissues as they phagocytosed blood-borne cellular material. Phagocytosis was circadianally regulated and mediated by distinct repertoires of receptors, opsonins, and transcription factors in macrophages from each tissue. Although the tissue of residence defined the core signature of macrophages, phagocytosis imprinted a distinct antiinflammatory profile. Phagocytic macrophages expressed CD206, displayed blunted expression of Il1b, and supported tissue homeostasis. Thus, phagocytosis is a source of macrophage heterogeneity that acts together with tissue-derived factors to preserve homeostasis.

引用

页码：1281 / 1296

页数：16

共 64 条

[1]

The nuclear receptor LXRα controls the functional specialization of splenic macrophages [J].

A-Gonzalez, Noelia ;

Guillen, Jose A. ;

Gallardo, German ;

Diaz, Mercedes ;

de la Rosa, Juan V. ;

Hernandez, Irene H. ;

Casanova-Acebes, Maria ;

Lopez, Felix ;

Tabraue, Carlos ;

Beceiro, Susana ;

Hong, Cynthia ;

Lara, Pedro C. ;

Andujar, Miguel ;

Arai, Satoko ;

Miyazaki, Toru ;

Li, Senlin ;

Corbi, Angel L. ;

Tontonoz, Peter ;

Hidalgo, Andres ;

Castrillo, Antonio .

NATURE IMMUNOLOGY, 2013, 14 (08) :831-+

[2]

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR [J].

A-Gonzalez, Noelia ;

Bensinger, Steven J. ;

Hong, Cynthia ;

Beceiro, Susana ;

Bradley, Michelle N. ;

Zelcer, Noam ;

Deniz, Jose ;

Ramirez, Cristina ;

Diaz, Mercedes ;

Gallardo, German ;

Ruiz de Galarreta, Carlos ;

Salazar, Jon ;

Lopez, Felix ;

Edwards, Peter ;

Parks, John ;

Andujar, Miguel ;

Tontonoz, Peter ;

Castrillo, Antonio .

IMMUNITY, 2009, 31 (02) :245-258

[3]

Phagocytosis of apoptotic cells in homeostasis [J].

Arandjelovic, Sanja ;

Ravichandran, Kodi S. .

NATURE IMMUNOLOGY, 2015, 16 (09) :907-917

[4]

Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer [J].

Bosurgi, Lidia ;

Bernink, Jochem H. ;

Cuevas, Victor Delgado ;

Gagliani, Nicola ;

Joannas, Leonel ;

Schmid, Edward T. ;

Booth, Carmen J. ;

Ghosh, Sourav ;

Rothlin, Carla V. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (32) :13091-13096

[5]

Phagoptosis - Cell Death By Phagocytosis - Plays Central Roles in Physiology, Host Defense and Pathology [J].

Brown, G. C. ;

Vilalta, A. ;

Fricker, M. .

CURRENT MOLECULAR MEDICINE, 2015, 15 (09) :842-851

[6]

Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance [J].

Casanova-Acebes, Maria ;

Pitaval, Christophe ;

Weiss, Linnea A. ;

Nombela-Arrieta, Cesar ;

Chevre, Raphael ;

A-Gonzalez, Noelia ;

Kunisaki, Yuya ;

Zhang, Dachuan ;

van Rooijen, Nico ;

Silberstein, Leslie E. ;

Weber, Christian ;

Nagasawa, Takashi ;

Frenette, Paul S. ;

Castrillo, Antonio ;

Hidalgo, Andres .

CELL, 2013, 153 (05) :1025-1035

[7]

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles [J].

Colombo, Marina ;

Raposo, Graca ;

Thery, Clotilde .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30, 2014, 30 :255-289

[8]

Annexin A1 regulates neutrophil clearance by macrophages in the mouse bone marrow [J].

Dalli, Jesmond ;

Jones, Carla P. ;

Cavalcanti, Danielle M. ;

Farsky, Sandra H. ;

Perretti, Mauro ;

Rankin, Sara M. .

FASEB JOURNAL, 2012, 26 (01) :387-396

[9]

Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis [J].

Damazo, Amilcar S. ;

Sampaio, Andre L. F. ;

Nakata, Cintia M. A. G. ;

Flower, Roderick J. ;

Perretti, Mauro ;

Oliani, Sonia M. .

BMC IMMUNOLOGY, 2011, 12

[10]

Tissue-resident macrophages [J].

Davies, Luke C. ;

Jenkins, Stephen J. ;

Allen, Judith E. ;

Taylor, Philip R. .

NATURE IMMUNOLOGY, 2013, 14 (10) :986-995

← 1 2 3 4 5 6 7 →