Transcriptional profiling identifies Id2 function in dendritic cell development

被引：400

作者：

Hacker, C

Kirsch, RD

Ju, XS

Hieronymus, T

Gust, TC

Kuhl, C

Jorgas, T

Kurz, SM

Rose-John, S

Yokota, Y

Zenke, M

机构：

[1] Max Delbruck Ctr Mol Med, MDC, D-13092 Berlin, Germany

[2] Univ Kiel, Dept Biochem, D-24098 Kiel, Germany

[3] Fukui Med Univ, Dept Biochem, Fukui, Japan

来源：

NATURE IMMUNOLOGY | 2003年 / 4卷 / 04期

关键词：

D O I：

10.1038/ni903

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) are potent antigen-presenting cells with a pivotal role in antigen-specific immune responses. Here, we found that the helix-loop-helix transcription factor Id2 is up-regulated during DC development in vitro and crucial for the development of distinct DC subsets in vivo. Id2(-/-) mice lack Langerhans cells (LCs), the cutaneous contingent of DCs, and the splenic CD8alpha(+) DC subset is markedly reduced. Mice deficient for transforming growth factor (TGF)-beta also lack LCs, and we demonstrate here that, in DCs, TGF-beta induces Id2 expression. We also show that Id2 represses B cell genes in DCs. These findings reveal a TGF-beta-Id2 signaling pathway in DCs and suggest a mechanism by which Id2 affects the lineage choice of B cell and DC progenitors.

引用

收藏

页码：380 / 386

页数：7

相关论文

共 53 条

[1] Origin and differentiation of dendritic cells [J].

Ardavín, C ;

del Hoyo, GM ;

Martín, P ;

Anjuère, F ;

Arias, CF ;

Marín, AR ;

Ruiz, S ;

Parrillas, V ;

Hernández, H .

TRENDS IN IMMUNOLOGY, 2001, 22 (12) :691-700

[2] Mouse type IIFN-producing cells are immature APCs with plasmacytoid morphology [J].

Asselin-Paturel, C ;

Boonstra, A ;

Dalod, M ;

Durand, I ;

Yessaad, N ;

Dezutter-Dambuyant, C ;

Vicari, A ;

O'Garra, A ;

Biron, C ;

Brière, F ;

Trinchieri, G .

NATURE IMMUNOLOGY, 2001, 2 (12) :1144-1150

[3] Immunobiology of dendritic cells [J].

Banchereau, J ;

Briere, F ;

Caux, C ;

Davoust, J ;

Lebecque, S ;

Liu, YT ;

Pulendran, B ;

Palucka, K .

ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :767-+

[4] Dendritic cells and the control of immunity [J].

Banchereau, J ;

Steinman, RM .

NATURE, 1998, 392 (6673) :245-252

[5] Id2 negatively regulates B cell differentiation in the spleen [J].

Becker-Herman, S ;

Lantner, F ;

Shachar, I .

JOURNAL OF IMMUNOLOGY, 2002, 168 (11) :5507-5513

[6] DENDRITIC CELL PROGENITOR IS TRANSFORMED BY A CONDITIONAL V-REL ESTROGEN-RECEPTOR FUSION PROTEIN V-REIER [J].

BOEHMELT, G ;

MADRUGA, J ;

DORFLER, P ;

BRIEGEL, K ;

SCHWARZ, H ;

ENRIETTO, PJ ;

ZENKE, M .

CELL, 1995, 80 (02) :341-352

[7] A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: The skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells [J].

Borkowski, TA ;

Letterio, JJ ;

Farr, AG ;

Udey, MC .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (06) :2417-2422

[8] Overexpression of Stra13 a novel retinoic acid-inducible gene of the basic helix-loop-helix family, inhibits mesodermal and promotes neuronal differentiation of P19 cells [J].

Boudjelal, M ;

Taneja, R ;

Matsubara, S ;

Bouillet, P ;

Dolle, P ;

Chambon, P .

GENES & DEVELOPMENT, 1997, 11 (16) :2052-2065

[9] EXPRESSION OF RELB IS REQUIRED FOR THE DEVELOPMENT OF THYMIC MEDULLA AND DENDRITIC CELLS [J].

BURKLY, L ;

HESSION, C ;

OGATA, L ;

REILLY, C ;

MARCONI, LA ;

OLSON, D ;

TIZARD, R ;

CATE, R ;

LO, D .

NATURE, 1995, 373 (6514) :531-536

[10] Characterization of a common precursor population for dendritic cells [J].

del Hoyo, GM ;

Martín, P ;

Vargas, HH ;

Ruiz, S ;

Arias, CF ;

Ardavin, C .

NATURE, 2002, 415 (6875) :1043-1047

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