Transcriptional modulation of foreign gene expression in engineered somatic tissues

被引：10

作者：

Bohl, D ^{[1
]}

Heard, JM ^{[1
]}

机构：

[1] Inst Pasteur, Lab Retrovirus & Transfert Genet, F-75724 Paris, France

来源：

CELL BIOLOGY AND TOXICOLOGY | 1998年 / 14卷 / 02期

关键词：

gene therapy; regulation; transcription;

D O I：

10.1023/A:1007480419685

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Many diseases that are candidates for gene therapy require that the therapeutic gene expression level be controlled to ensure biological efficacy and to prevent toxic effects. Various systems have been described that allow transcriptional regulation by artificial chimeric transactivators in mammalian cells. This paper describes these various systems and discusses their interests for gene therapy.

引用

页码：83 / 94

页数：12

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