HER2/HER3 heterodimers in prostate cancer: Whither HER1/EGFR?

被引：21

作者：

Freeman, MR ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Childrens Hosp Boston, Urol Dis Res Ctr,Enders Res Labs, Boston, MA 02115 USA

来源：

CANCER CELL | 2004年 / 6卷 / 05期

关键词：

D O I：

10.1016/j.ccr.2004.10.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this issue of Cancer Cell, Mellinghoff et al. (2004) demonstrate that a small molecule inhibitor of the EGF receptor (EGFR) and the HER2/ErbB2/c-Neu kinase blocks signaling to the androgen receptor by a mechanism that involves HER2/HER3 heterodimerization. Surprisingly, the EGFR is peripheral to this signaling mechanism. These results have implications for the design of targeted therapy for hormone-refractory prostate cancer.

引用

收藏

页码：427 / 428

页数：2

相关论文

共 11 条

[1] Heparin-binding epidermal growth factor-like growth factor stimulates androgen-independent prostate tumor growth and antagonizes androgen receptor function [J].

Adam, RM ;

Kim, J ;

Lin, JQ ;

Orsola, A ;

Zhuang, LY ;

Rice, DC ;

Freeman, MR .

ENDOCRINOLOGY, 2002, 143 (12) :4599-4608

[2]

Bruns CJ, 2000, CANCER RES, V60, P2926

[3]

CULIG Z, 1994, CANCER RES, V54, P5474

[4] Androgen receptor phosphorylation - Regulation and identification of the phosphorylation sites. [J].

Gioeli, D ;

Ficarro, SB ;

Kwiek, JJ ;

Aaronson, D ;

Hancock, M ;

Catling, AD ;

White, FM ;

Christian, RE ;

Settlage, RE ;

Shabanowitz, J ;

Hunt, DF ;

Weber, MJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (32) :29304-29314

[5] Androgen receptor outwits prostate cancer drugs [J].

Isaacs, JT ;

Isaacs, WB .

NATURE MEDICINE, 2004, 10 (01) :26-27

[6] Phosphorylation of Akt (Ser473) is an excellent predictor of poor clinical outcome in prostate cancer [J].

Kreisberg, JI ;

Malik, SN ;

Prihoda, TJ ;

Bedolla, RG ;

Troyer, DA ;

Kreisberg, S ;

Ghosh, PM .

CANCER RESEARCH, 2004, 64 (15) :5232-5236

[7] Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor [J].

Lin, HK ;

Yeh, SY ;

Kang, HY ;

Chang, CS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (13) :7200-7205

[8] Targeting the PI3K-Akt pathway in human cancer: Rationale and promise [J].

Luo, J ;

Manning, BD ;

Cantley, LC .

CANCER CELL, 2003, 4 (04) :257-262

[9] STUDIES OF THE HER-2/NEU PROTO-ONCOGENE IN HUMAN-BREAST AND OVARIAN-CANCER [J].

SLAMON, DJ ;

GODOLPHIN, W ;

JONES, LA ;

HOLT, JA ;

WONG, SG ;

KEITH, DE ;

LEVIN, WJ ;

STUART, SG ;

UDOVE, J ;

ULLRICH, A ;

PRESS, MF .

SCIENCE, 1989, 244 (4905) :707-712

[10]

Wen Y, 2000, CANCER RES, V60, P6841