A mechanistic study of 3-aminoindazole cyclic urea HIV-1 protease inhibitors using comparative QSAR

被引：21

作者：

Garg, R ^{[1
]}

Bhhatarai, B ^{[1
]}

机构：

[1] Clarkson Univ, Dept Chem, Potsdam, NY 13699 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 22期

关键词：

HIV-1-protease; comparative QSAR; 3-aminoindazole cyclic urea; hydrophobicity;

D O I：

10.1016/j.bmc.2004.08.036

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Comparative QSAR studies on P2/P2' and P1/P1' substituted symmetrical and nonsymmetrical 3-aminoindazole cyclic urea HIV-1 protease inhibitors were performed. The protease inhibitory activity of these compounds was found to decrease with larger and more hydrophobic molecules, whereas the antiviral potency and translation across the cell membrane increases with increase in hydrophobicity and size. These results provide mechanistic insight about the mode of interaction of these compounds with HIV-1 protease receptor and would help in further improving the biological activity. (C) 2004 Elsevier Ltd. All rights reserved.

引用

收藏

页码：5819 / 5831

页数：13

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