Synthesis and insect growth regulatory activity of alkoxy-substituted benzaldoxime ethers

被引:9
作者
Chowdhury, H
Saxena, VS
Walia, S [1 ]
机构
[1] Indian Agr Res Inst, Div Agr Chem, New Delhi 110012, India
[2] Indian Agr Res Inst, Div Entomol, New Delhi 110012, India
关键词
insect growth regulators; oxime ethers; Schistocerca gregaria;
D O I
10.1021/jf970062h
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
Alkoxy-substituted benzaldoxime ethers, namely (i) 3-methoxy-4-ethoxybenzaldoxime N-O-alkyl ethers, (ii) 3,4-dimethoxybenzaldoxime N-O-alkyl ethers, and (iii) 3,4-methylenedioxybenzaldoxime N-O-alkyl ethers, have been synthesized and evaluated for their insect growth regulatory activity against fifth-instar nymphs of the desert locust Schistocerca gregaria F. When injected into insect hemolymph at the lowest dose level of 3 mu g/nymph, 3,4-methylenedioxybenzaldoxime N-O-methyl ether and 3,4-methylenedioxybenzaldoxime N-O-isopropyl ether showed 40 and 50% growth deformities respectively. On topical application (at 20 mu g/nymph) 3-methoxy-4-ethoxybenzaldoxime N-O-methyl ether inflicted 100% abnormalities in insect growth. Structure-activity relationship studies revealed that maximum activity was associated with compounds having three carbons in the oxime ether moiety.
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页码:731 / 736
页数:6
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