Cardiac angiotensin II receptors are downregulated by chronic angiotensin II infusion in rats

被引：5

作者：

Katoh, M

Egashira, K

Takeshita, A

机构：

[1] Tanabe Seiyaku Co Ltd, Discovery Res Lab, Toda, Saitama 3358505, Japan

[2] Kyushu Univ, Fac Med, Dept Cardiovasc Med, Higashi Ku, Fukuoka 8128582, Japan

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 2000年 / 84卷 / 01期

关键词：

angiotensin II; angiotensin receptor; rat left ventricle;

D O I：

10.1254/jjp.84.75

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We studied the effect of chronic (7 days) angiotensin II infusion in a subpressor (200 ng/kg per minute) dose on angiotensin II receptors in the left ventricle in rats. Infusion of angiotensin II caused an elevation in systolic blood pressure after 3 days, usually to values of about 150 mmHg, and the increase continued during the drug administration. The number of angiotensin II type 1 and angiotensin II type 2 receptors was significantly decreased by 20 - 30% in the angiotensin II-infused left ventricular membranes without affecting the affinity. Thus, these data suggest that angiotensin II may regulate the number of its own receptors in rat left ventricles.

引用

收藏

页码：75 / 77

页数：3

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