AIP1: a new player in TNF signaling

被引：25

作者：

Guicciardi, ME ^{[1
]}

Gores, GJ ^{[1
]}

机构：

[1] Mayo Clin & Mayo Fdn, Sch Med, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2003年 / 111卷 / 12期

关键词：

D O I：

10.1172/JCI200318911

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

Apoptosis signal-regulating kinase 1 (ASK1) is an upstream activator of JNK and p38 MAPK signaling cascades. Evidence now shows (see the related article beginning on page 1933) that the ASK1-interacting protein, AIP1, plays an important role in TNF-alpha-induced ASK1 activation by facilitating dissociation from its inhibitor.

引用

页码：1813 / 1815

页数：3

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