Follicular dendritic cells in TSE pathogenesis

被引：47

作者：

Bruce, ME

Brown, KL

Mabbott, NA

Farquhar, CF

Jeffrey, M

机构：

[1] Inst Anim Hlth, Neuropathogenesis Unit, Edinburgh EH9 3JF, Midlothian, Scotland

[2] VLA Lasswade, Penicuik EH26 0PZ, Midlothian, Scotland

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 09期

关键词：

D O I：

10.1016/S0167-5699(00)01696-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The pathogenesis of transmissible spongiform encephalopathies (TSEs) often includes a replication phase in lymphoid tissues before infection spreads to the central nervous system. Recent studies show that the follicular dendritic cells of the germinal centres are critical for this replication. These cells are therefore potential targets for therapy or prophylaxis in natural TSEs, such as variant Creutzfeldt-Jakob disease.

引用

页码：442 / 446

页数：5

共 41 条

[1] PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain
Blattler, T
Brandner, S
Raeber, AJ
Klein, MA
Voigtlander, T
Weissmann, C
Aguzzi, A
[J]. NATURE, 1997, 389 (6646) : 69 - 73
[2] IDENTIFICATION OF A PROTEIN THAT PURIFIES WITH THE SCRAPIE PRION
BOLTON, DC
MCKINLEY, MP
PRUSINER, SB
[J]. SCIENCE, 1982, 218 (4579) : 1309 - 1311
[3] A SEVERE COMBINED IMMUNODEFICIENCY MUTATION IN THE MOUSE
BOSMA, GC
CUSTER, RP
BOSMA, MJ
[J]. NATURE, 1983, 301 (5900) : 527 - 530
[4] Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells
Brown, KL
Stewart, K
Ritchie, DL
Mabbott, NA
Williams, A
Fraser, H
Morrison, WI
Bruce, ME
[J]. NATURE MEDICINE, 1999, 5 (11) : 1308 - 1312
[5] SCRAPIE STRAIN VARIATION AND MUTATION
BRUCE, ME
[J]. BRITISH MEDICAL BULLETIN, 1993, 49 (04) : 822 - 838
[6] Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent
Bruce, ME
Will, RG
Ironside, JW
McConnell, I
Drummond, D
Suttie, A
McCardle, L
Chree, A
Hope, J
Birkett, C
Cousens, S
Fraser, H
Bostock, CJ
[J]. NATURE, 1997, 389 (6650) : 498 - 501
[7] MICE DEVOID OF PRP ARE RESISTANT TO SCRAPIE
BUELER, H
AGUZZI, A
SAILER, A
GREINER, RA
AUTENRIED, P
AGUET, M
WEISSMANN, C
[J]. CELL, 1993, 73 (07) : 1339 - 1347
[8] SCRAPIE INFECTIVITY, FIBRILS AND LOW-MOLECULAR WEIGHT PROTEIN
DIRINGER, H
GELDERBLOM, H
HILMERT, H
OZEL, M
EDELBLUTH, C
KIMBERLIN, RH
[J]. NATURE, 1983, 306 (5942) : 476 - 478
[9] Replication of scrapie in spleens of SCID mice follows reconstitution with wild-type mouse bone marrow
Fraser, H
Brown, KL
Stewart, K
McConnell, I
McBride, P
Williams, A
[J]. JOURNAL OF GENERAL VIROLOGY, 1996, 77 : 1935 - 1940
[10] STUDIES OF LYMPHORETICULAR-SYSTEM IN PATHOGENESIS OF SCRAPIE - ROLE OF SPLEEN AND THYMUS
FRASER, H
DICKINSON, AG
[J]. JOURNAL OF COMPARATIVE PATHOLOGY, 1978, 88 (04) : 563 - 573

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