Follicular dendritic cells in TSE pathogenesis

被引：47

作者：

Bruce, ME

Brown, KL

Mabbott, NA

Farquhar, CF

Jeffrey, M

机构：

[1] Inst Anim Hlth, Neuropathogenesis Unit, Edinburgh EH9 3JF, Midlothian, Scotland

[2] VLA Lasswade, Penicuik EH26 0PZ, Midlothian, Scotland

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 09期

关键词：

D O I：

10.1016/S0167-5699(00)01696-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The pathogenesis of transmissible spongiform encephalopathies (TSEs) often includes a replication phase in lymphoid tissues before infection spreads to the central nervous system. Recent studies show that the follicular dendritic cells of the germinal centres are critical for this replication. These cells are therefore potential targets for therapy or prophylaxis in natural TSEs, such as variant Creutzfeldt-Jakob disease.

引用

页码：442 / 446

页数：5

共 41 条

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