Desmosomes: a role in cancer?

被引：141

作者：

Chidgey, M.

Dawson, C.

机构：

[1] Univ Birmingham, Queen Elizabeth Hosp, Div Med Sci, Birmingham B15 2TH, W Midlands, England

[2] Univ Birmingham, Inst Canc Studies, Canc Res UK, Birmingham B15 2TT, W Midlands, England

来源：

BRITISH JOURNAL OF CANCER | 2007年 / 96卷 / 12期

关键词：

desmosome; desmocollin; desmoglein; plakoglobin; EMT;

D O I：

10.1038/sj.bjc.6603808

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Much evidence now attests to the importance of desmosomes and their constituents in cancer. Alterations in the expression of desmosomal components could contribute to the progression of the disease by modifying intracellular signal transduction pathways and/or by causing reduced cell adhesion. The Wnt/beta-catenin pathway is a potential target because of the involvement of the cytoplasmic desmosomal protein plakoglobin. Loss of desmosomal adhesion is a prerequisite for the epithelial-mesenchymal transition, implicated in the conversion of early stage tumours to invasive cancers.

引用

收藏

页码：1783 / 1787

页数：5

相关论文

共 42 条

[1] THE HUMAN PLAKOGLOBIN GENE LOCALIZES ON CHROMOSOME 17Q21 AND IS SUBJECTED TO LOSS OF HETEROZYGOSITY IN BREAST AND OVARIAN CANCERS [J].

ABERLE, H ;

BIERKAMP, C ;

TORCHARD, D ;

SEROVA, O ;

WAGNER, T ;

NATT, E ;

WIRSCHING, J ;

HEIDKAMPER, C ;

MONTAGNA, M ;

LYNCH, HT ;

LENOIR, GM ;

SCHERER, G ;

FEUNTEUN, J ;

KEMLER, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (14) :6384-6388

[2] The transcription factor ZEB1 (δEF1) represses Plakophilin 3 during human cancer progression [J].

Aigner, Kirsten ;

Descovich, Luise ;

Mikula, Mario ;

Sultan, Aneesa ;

Dampier, Brigitta ;

Bonne, Stefan ;

van Roy, Frans ;

Mikulits, Wolfgang ;

Schreiber, Martin ;

Brabletz, Thomas ;

Sommergruber, Wolfgang ;

Schweifer, Norbert ;

Wernitznig, Andreas ;

Beug, Hartmut ;

Foisner, Roland ;

Eger, Andreas .

FEBS LETTERS, 2007, 581 (08) :1617-1624

[3] Desmoglein 2 is expressed abnormally rather than mutated in familial and sporadic gastric cancer [J].

Biedermann, K ;

Vogelsang, H ;

Becker, I ;

Plaschke, S ;

Siewert, JR ;

Höfler, H ;

Keller, G .

JOURNAL OF PATHOLOGY, 2005, 207 (02) :199-206

[4] Suprabasal Dsg2 expression in transgenic mouse skin confers a hyperproliferative and apoptosis-resistant phenotype to keratinocytes [J].

Brennan, Donna ;

Hu, Ying ;

Joubeh, Sohaila ;

Choi, Yoo Won ;

Whitaker-Menezes, Diana ;

O'Brien, Thomas ;

Uitto, Jouni ;

Rodeck, Ulrich ;

Mahoney, My G. .

JOURNAL OF CELL SCIENCE, 2007, 120 (05) :758-771

[5] Histone deacetylase inhibitors upregulate plakoglobin expression in bladder carcinoma cells and display antineoplastic activity in vitro and in vivo [J].

Canes, D ;

Chiang, GJ ;

Billmeyer, BR ;

Austin, CA ;

Kosakowski, M ;

Rieger-Christ, KM ;

Libertino, JA ;

Summerhayes, IC .

INTERNATIONAL JOURNAL OF CANCER, 2005, 113 (05) :841-848

[6] Protein binding and functional characterization of plakophilin 2 -: Evidence for its diverse roles in desmosomes and β-catenin signaling [J].

Chen, XY ;

Bonné, S ;

Hatzfeld, M ;

van Roy, F ;

Green, KJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (12) :10512-10522

[7]

Cheng KKF, 2003, CANCER NURS, V26, P476

[8]

Chidgey M, 2002, HISTOL HISTOPATHOL, V17, P1179, DOI 10.14670/HH-17.1179

[9] Nr-CAM is a target gene of the β-catenin/LEF-1 in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis [J].

Conacci-Sorrell, ME ;

Ben-Yedidia, T ;

Shtutman, M ;

Feinstein, E ;

Einat, P ;

Ben-Ze'ev, A .

GENES & DEVELOPMENT, 2002, 16 (16) :2058-2072

[10] Rho GTPase expression in tumourigenesis:: evidence for a significant link [J].

del Pulgar, TG ;

Benitah, SA ;

Valerón, PF ;

Espina, C ;

Lacal, JC .

BIOESSAYS, 2005, 27 (06) :602-613

← 1 2 3 4 5 →