Desmosomes: a role in cancer?

被引：141

作者：

Chidgey, M.

Dawson, C.

机构：

[1] Univ Birmingham, Queen Elizabeth Hosp, Div Med Sci, Birmingham B15 2TH, W Midlands, England

[2] Univ Birmingham, Inst Canc Studies, Canc Res UK, Birmingham B15 2TT, W Midlands, England

来源：

BRITISH JOURNAL OF CANCER | 2007年 / 96卷 / 12期

关键词：

desmosome; desmocollin; desmoglein; plakoglobin; EMT;

D O I：

10.1038/sj.bjc.6603808

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Much evidence now attests to the importance of desmosomes and their constituents in cancer. Alterations in the expression of desmosomal components could contribute to the progression of the disease by modifying intracellular signal transduction pathways and/or by causing reduced cell adhesion. The Wnt/beta-catenin pathway is a potential target because of the involvement of the cytoplasmic desmosomal protein plakoglobin. Loss of desmosomal adhesion is a prerequisite for the epithelial-mesenchymal transition, implicated in the conversion of early stage tumours to invasive cancers.

引用

收藏

页码：1783 / 1787

页数：5

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