Protection but maintained dysfunction of nigral dopaminergic nerve cell bodies and striatal dopaminergic terminals in MPTP-lesioned mice after acute treatment with the mGluR5 antagonist MPEP

被引：49

作者：

Aguirre, JA

Kehr, J

Yoshitake, T

Liu, FL

Rivera, A

Fernandez-Espinola, S

Andbjer, B

Leo, G

Medhurst, AD

Agnati, LF

Fuxe, K

机构：

[1] Univ Malaga, Dept Human Physiol, Sch Med, E-29071 Malaga, Spain

[2] Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden

[3] Beijing Military Gen Hosp, Dept Neurol, Beijing 100700, Peoples R China

[4] Univ Malaga, Dept Cell Biol, Sch Sci, E-29071 Malaga, Spain

[5] Univ Modena, Dept Biomed Sci, I-41100 Modena, Italy

[6] GlaxoSmithKline, Neurodegenerat Res, Neurol GI Ctr Excellence Drug Discovery, Essex, England

来源：

BRAIN RESEARCH | 2005年 / 1033卷 / 02期

关键词：

metabotropic glutamate receptor mGluR5; basal ganglia; MPTP; neuroprotection; stereology; DA metabolism;

D O I：

10.1016/j.brainres.2004.11.040

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The mGluR5 antagonist MPEP was used to study the role of mGluR5 in MPTP-induced injury of the nigrostriatal DA neurons. The findings indicate that acute blockade of mGluR5 may result in neuroprotective actions against MPTP neurotoxicity on nigral DA cell bodies and striatal DA terminals using stereological analysis of TH immunoreactivity and microdensitometry. Biochemical analysis showed no restoration of DA levels and metabolism indicating a maintained reduction of DA transmission. (C) 2004 Elsevier B.V All rights reserved.

引用

页码：216 / 220

页数：5

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