Capitalizing on large-scale mouse mutagenesis screens

被引：71

作者：

Justice, MJ ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

来源：

NATURE REVIEWS GENETICS | 2000年 / 1卷 / 02期

关键词：

D O I：

10.1038/35038549

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Variation is the crux of genetics. Mutagenesis screens in organisms from bacteria to fish have provided a battery of mutants that define protein functions within complex pathways. Large-scale mutation isolation has been carried out in Caenorhabditis elegans, Drosophila melanogaster and zebrafish, and has been recently reported in the mouse in two screens that have generated many new, clinically relevant mutations to reveal the power of phenotype-driven screens in a mammal.

引用

页码：109 / 115

页数：7

共 38 条

[1] A large-scale insertional mutagenesis screen in zebrafish [J].

Amsterdam, A ;

Burgess, S ;

Golling, G ;

Chen, WB ;

Sun, ZX ;

Townsend, K ;

Farrington, S ;

Haldi, M ;

Hopkins, N .

GENES & DEVELOPMENT, 1999, 13 (20) :2713-2724

[2]

Anderson P, 1995, METHOD CELL BIOL, V48, P31

[3] An action plan for mouse genomics [J].

Battey, J ;

Jordan, E ;

Cox, D ;

Dove, W .

NATURE GENETICS, 1999, 21 (01) :73-75

[4] Ten years of enhancer detection: Lessons from the fly [J].

Bellen, HJ .

PLANT CELL, 1999, 11 (12) :2271-2281

[5] The mouse genome database (MGD): genetic and genomic information about the laboratory mouse [J].

Blake, JA ;

Richardson, JE ;

Davisson, MT ;

Eppig, JT .

NUCLEIC ACIDS RESEARCH, 1999, 27 (01) :95-98

[6] ALTERING THE GENOME BY HOMOLOGOUS RECOMBINATION [J].

CAPECCHI, MR .

SCIENCE, 1989, 244 (4910) :1288-1292

[7] Genotype-based screen for ENU-induced mutations in mouse embryonic stem cells [J].

Chen, YJ ;

Yee, D ;

Dains, K ;

Chatterjee, A ;

Cavalcoli, J ;

Schneider, E ;

Om, J ;

Woychik, RP ;

Magnuson, T .

NATURE GENETICS, 2000, 24 (03) :314-317

[8] Genome-wide, large-scale production of mutant mice by ENU mutagenesis [J].

de Angelis, MH ;

Flaswinkel, H ;

Fuchs, H ;

Rathkolb, B ;

Soewarto, D ;

Marschall, S ;

Heffner, S ;

Pargent, W ;

Wuensch, K ;

Jung, M ;

Reis, A ;

Richter, T ;

Alessandrini, F ;

Jakob, T ;

Fuchs, E ;

Kolb, H ;

Kremmer, E ;

Schaeble, K ;

Rollinski, B ;

Roscher, A ;

Peters, C ;

Meitinger, T ;

Strom, T ;

Steckler, T ;

Holsboer, F ;

Klopstock, T ;

Gekeler, F ;

Schindewolf, C ;

Jung, T ;

Avraham, K ;

Behrendt, H ;

Ring, J ;

Zimmer, A ;

Schughart, K ;

Pfeffer, K ;

Wolf, E ;

Balling, R .

NATURE GENETICS, 2000, 25 (04) :444-447

[9] Mouse as the measure of man? [J].

Denny, P ;

Justice, MJ .

TRENDS IN GENETICS, 2000, 16 (07) :283-287

[10]

Driever W, 1996, DEVELOPMENT, V123, P37

← 1 2 3 4 →