Unified perspective on proteins: A physics approach

被引:54
作者
Banavar, JR [1 ]
Hoang, TX
Maritan, A
Seno, F
Trovato, A
机构
[1] Penn State Univ, Dept Phys, Davey Lab 104, University Pk, PA 16802 USA
[2] VAST, Inst Phys & Elect, Hanoi, Vietnam
[3] Univ Padua, INFM, I-35131 Padua, Italy
[4] Univ Padua, Dipartimento Fis G Galilei, I-35131 Padua, Italy
基金
美国国家科学基金会;
关键词
D O I
10.1103/PhysRevE.70.041905
中图分类号
O35 [流体力学]; O53 [等离子体物理学];
学科分类号
070204 ; 080103 ; 080704 ;
摘要
We study a physical system which, while devoid of the complexity one usually associates with proteins, nevertheless displays a remarkable array of proteinlike properties. The constructive hypothesis that this striking resemblance is not accidental not only leads to a unified framework for understanding protein folding, amyloid formation, and protein interactions but also has implications for natural selection.
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页数:25
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共 188 条
[71]   How enzymes work: Analysis by modern rate theory and computer simulations [J].
Garcia-Viloca, M ;
Gao, J ;
Karplus, M ;
Truhlar, DG .
SCIENCE, 2004, 303 (5655) :186-195
[72]   Functional organization of the yeast proteome by systematic analysis of protein complexes [J].
Gavin, AC ;
Bösche, M ;
Krause, R ;
Grandi, P ;
Marzioch, M ;
Bauer, A ;
Schultz, J ;
Rick, JM ;
Michon, AM ;
Cruciat, CM ;
Remor, M ;
Höfert, C ;
Schelder, M ;
Brajenovic, M ;
Ruffner, H ;
Merino, A ;
Klein, K ;
Hudak, M ;
Dickson, D ;
Rudi, T ;
Gnau, V ;
Bauch, A ;
Bastuck, S ;
Huhse, B ;
Leutwein, C ;
Heurtier, MA ;
Copley, RR ;
Edelmann, A ;
Querfurth, E ;
Rybin, V ;
Drewes, G ;
Raida, M ;
Bouwmeester, T ;
Bork, P ;
Seraphin, B ;
Kuster, B ;
Neubauer, G ;
Superti-Furga, G .
NATURE, 2002, 415 (6868) :141-147
[73]  
GINSBURG ANN, 1965, BIOCHEMISTRY, V4, P2159, DOI 10.1021/bi00886a033
[74]   Co-evolutionary analysis reveals insights into protein-protein interactions [J].
Goh, CS ;
Cohen, FE .
JOURNAL OF MOLECULAR BIOLOGY, 2002, 324 (01) :177-192
[75]   Global curvature, thickness, and the ideal shapes of knots [J].
Gonzalez, O ;
Maddocks, JH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (09) :4769-4773
[76]   Global curvature and self-contact of nonlinearly elastic curves and rods [J].
Gonzalez, O ;
Maddocks, JH ;
Schuricht, F ;
von der Mosel, H .
CALCULUS OF VARIATIONS AND PARTIAL DIFFERENTIAL EQUATIONS, 2002, 14 (01) :29-68
[77]   CHARACTERIZATION OF A PARTIALLY DENATURED STATE OF A PROTEIN BY 2-DIMENSIONAL NMR - REDUCTION OF THE HYDROPHOBIC INTERACTIONS IN UBIQUITIN [J].
HARDING, MM ;
WILLIAMS, DH ;
WOOLFSON, DN .
BIOCHEMISTRY, 1991, 30 (12) :3120-3128
[78]   DENOVO DESIGN, EXPRESSION, AND CHARACTERIZATION OF FELIX - A 4-HELIX BUNDLE PROTEIN OF NATIVE-LIKE SEQUENCE [J].
HECHT, MH ;
RICHARDSON, JS ;
RICHARDSON, DC ;
OGDEN, RC .
SCIENCE, 1990, 249 (4971) :884-891
[79]   FOLDING AND FUNCTION OF A T4 LYSOZYME CONTAINING 10 CONSECUTIVE ALANINES ILLUSTRATE THE REDUNDANCY OF INFORMATION IN AN AMINO-ACID-SEQUENCE [J].
HEINZ, DW ;
BAASE, WA ;
MATTHEWS, BW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (09) :3751-3755
[80]   CRYSTAL-STRUCTURE OF ALPHA-1 - IMPLICATIONS FOR PROTEIN DESIGN [J].
HILL, CP ;
ANDERSON, DH ;
WESSON, L ;
DEGRADO, WF ;
EISENBERG, D .
SCIENCE, 1990, 249 (4968) :543-546