Molecular and cellular mechanisms in spermatogenesis

被引：86

作者：

Grootegoed, JA ^{[1
]}

Siep, M ^{[1
]}

Baarends, WM ^{[1
]}

机构：

[1] Erasmus Univ, Dept Endocrinol & Reprod, NL-3000 DR Rotterdam, Netherlands

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2000年 / 14卷 / 03期

关键词：

spermatogenesis; meiosis; gene expression;

D O I：

10.1053/beem.2000.0083

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mammalian spermatogenesis shows a strict control of many specific molecular and cellular events. This control involves Sertoli cell-germ cell interaction, as well as a programmed performance of changes in chromatin structure and gene expression in the developing germ cells. In recent years, much knowledge about the functions of defined genes in spermatogenesis has been gained by making use of mouse transgenic and gene knockout models. Several of these models are discussed in this brief overview, with an emphasis on genes encoding proteins involved in the control of gene transcription, mRNA translation, DNA repair and protein ubiquitination. A better understanding of the molecular and cellular biology of spermatogenesis in the mouse may provide concepts that can improve our understanding of human male infertility and may also lead to the identification of novel targets for contraceptive intervention.

引用

页码：331 / 343

页数：13

共 89 条

[71] The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis [J].

Ruggiu, M ;

Speed, R ;

Taggart, M ;

McKay, SJ ;

Kilanowski, F ;

Saunders, P ;

Dorin, J ;

Cooke, HJ .

NATURE, 1997, 389 (6646) :73-77

[72]

RUSSELL LD, 1993, SERTOLI CELL, P269

[73] Transcriptional checkpoints determining the fate of male germ cells [J].

SassoneCorsi, P .

CELL, 1997, 88 (02) :163-166

[74] Human and mouse XAP-5 and XAP-5-like (X5L) genes:: Identification of an ancient functional retroposon differentially expressed in testis [J].

Sedlacek, Z ;

Münstermann, E ;

Dhorne-Pollet, S ;

Otto, C ;

Bock, D ;

Schütz, G ;

Poustka, A .

GENOMICS, 1999, 61 (02) :125-132

[75]

Sharpe Richard M., 1994, P1363

[76] REGULATION OF GENE-EXPRESSION IN SERTOLI CELLS BY FOLLICLE-STIMULATING-HORMONE (FSH) - CLONING AND CHARACTERIZATION OF LRPR1, A PRIMARY RESPONSE GENE ENCODING A LEUCINE-RICH PROTEIN [J].

SLEGTENHORSTEEGDEMAN, KE ;

POST, M ;

BAARENDS, WM ;

THEMMEN, APN ;

GROOTEGOED, JA .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1995, 108 (1-2) :115-124

[77] An azoospermic man with a de novo point mutation in the Y-chromosomal gene USP9Y [J].

Sun, C ;

Sklaetsky, H ;

Birren, B ;

Devon, K ;

Tang, ZL ;

Silber, S ;

Oates, R ;

Page, DC .

NATURE GENETICS, 1999, 23 (04) :429-432

[78] AN INTRON FACILITATES ACTIVATION OF THE CALSPERMIN GENE BY THE TESTIS-SPECIFIC TRANSCRIPTION FACTOR CREM-TAU [J].

SUN, ZM ;

MEANS, AR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (36) :20962-20967

[79]

Sutton KA, 1998, J ANDROL, V19, P21

[80] Mullerian-inhibiting substance regulates androgen synthesis at the transcriptional level [J].

Teixeira, J ;

Fynn-Thompson, E ;

Payne, AH ;

Donahoe, PK .

ENDOCRINOLOGY, 1999, 140 (10) :4732-4738

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