A light in multidrug resistance: Photodynamic treatment of multidrug-resistant tumors

被引：88

作者：

Capella, MAM ^{[1
]}

Capella, LS

机构：

[1] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, CCS Bloco G, BR-21949900 Rio De Janeiro, Brazil

[2] Univ Fed Rio de Janeiro, Dept Bioquimm Med, BR-21949900 Rio De Janeiro, Brazil

[3] Fed Univ Rio De Janeiro, Dept Clin Med, Rio De Janeiro, Brazil

来源：

JOURNAL OF BIOMEDICAL SCIENCE | 2003年 / 10卷 / 04期

关键词：

multidrug resistance; visible light; phototherapy; photosensitizer; review;

D O I：

10.1159/000071155

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The major drawback of cancer chemotherapy is the development of multidrug-resistant (MDR) tumor cells, which are cross-resistant to a broad range of structurally and functionally unrelated agents, making it difficult to treat these tumors. In the last decade, a number of authors have studied the effects of photodynamic therapy (PDT), a combination of visible light with photosensitizing agents, on MDR cells. The results, although still inconclusive, have raised the possibility of treating MDR tumors by PDT. This review examines the growing literature concerning the responses of MDR cells to PDT, while stressing the need for the development of new photosensitizers that possess the necessary characteristics for the photodynamic treatment of this class of tumor. Copyright (C) 2003 National Science Council, ROC and S. Karger AG, Basel.

引用

页码：361 / 366

页数：6

共 64 条

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