The Ndc80 complex: Hub of kinetochore activity

被引：66

作者：

Ciferri, Claudio

Musacchio, Andrea

Petrovic, Arsen

机构：

[1] European Inst Oncol, Dept Expt Oncol, I-20131 Milan, Italy

[2] Italian Inst Technol Fdn, Res Unit, I-20131 Milan, Italy

来源：

FEBS LETTERS | 2007年 / 581卷 / 15期

关键词：

kintochore; centromere; cancer; aneuploidy; Hecl; Ndc80; Nuf2; Spc24; Spc25; spindle assembly checkpoint; microtubule;

D O I：

10.1016/j.febslet.2007.05.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Kinetochores are protein scaffolds coordinating the process of chromosome segregation in mitosis. Kinetochore components are organized in functionally and topologically distinct domains that are designed to connect the sister chromatids to the mitotic spindle. The inner kinetochore proteins are in direct contact with the centromeric DNA, whilst the outer kinetochore proteins are responsible for binding to spindle microtubules. The conserved Ndc80 complex is implicated in several essential outer kinetochore functions, including microtubule binding and control of a safety device known as the spindle assembly checkpoint. Here, we describe how current work is contributing to unravel the complex endeavors of this essential kinetochore complex. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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页码：2862 / 2869

页数：8

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