RETRACTED: Use of albumin: an update (Retracted article. See vol. 125, pg. 417, 2020)

被引:116
作者
Boldt, J. [1 ]
机构
[1] Klinikum Stadt Ludwigshafen, Dept Anaesthesiol & Intens Care Med, D-67063 Ludwigshafen, Germany
关键词
blood; coagulation; loss; protein; plasma; surgery; TYPE-1; HEPATORENAL-SYNDROME; TRANSCAPILLARY ESCAPE RATE; TRIAL COMPARING ALBUMIN; HYDROXYETHYL STARCH; CIRRHOTIC-PATIENTS; CARDIAC-SURGERY; SERUM-ALBUMIN; TENSE ASCITES; TRANSFUSION REQUIREMENTS; INTRAVENOUS ALBUMIN;
D O I
10.1093/bja/aep393
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Human albumin (HA) is widely used for volume replacement or correction of hypoalbuminaemia. The value of HA in the clinical setting continues to be controversial, and it is unclear whether in today's climate of cost consciousness, there is still a place for such a highly priced substance. It is therefore appropriate to update our knowledge of the value of HA. With the exception of women in early pregnancy, there appears to be few indications for the use of HA to correct hypovolaemia. Some studies of traumatic brain injury and intensive care patients suggest negative effects on outcome and organ function of (hyperoncotic) HA. Modern synthetic colloids appear to be a cheaper alternative for maintaining colloid oncotic pressure. The value of using HA to correct hypoalbuminaemia has not been clearly justified. Theoretical and pharmacological benefits of HA, such as oxygen radical scavenging or binding of toxic substances, have not as yet been shown to have beneficial clinical consequences. Experimental data from cell lines or animals do not appear to mimic the clinical setting. Convincing data justifying the use of HA either for treating hypovolaemia or for correcting hypoalbuminaemia are still lacking. A restricted use of HA is recommended.
引用
收藏
页码:276 / 284
页数:9
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