Homology modelling and conformational analysis of IgE-binding epitopes of Ara h 3 and other legumin allergens with a cupin fold from tree nuts

被引：56

作者：

Barre, Annick ^{[1
]}

Jacquet, Geraldine ^{[1
]}

Sordet, Camille ^{[1
]}

Culerrier, Raphael ^{[1
]}

Rouge, Pierre ^{[1
]}

机构：

[1] CNRS, UPS, UMR 5546, F-31326 Castanet Tolosan, France

来源：

MOLECULAR IMMUNOLOGY | 2007年 / 44卷 / 12期

关键词：

Ana o 2; Ara h 3; Cor a 9; Jug r 4; peanut; tree nut; IgE-binding epitopes; three-dimensional models; allergy;

D O I：

10.1016/j.molimm.2007.01.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Linear IgE-binding epitopes identified in legumin allergens of peanut (Ara h 3) and other allergenic tree nuts (Jug r 4 of walnut, Cor a 9 of hazelnut, Ana o 2 cashew nut) were mapped on three-dimensional models of the proteins built up by homology modelling. A conformational analysis revealed that consensual surface-exposed IgE-binding epitopes exhibited some structural homology susceptible to account for the IgE-binding cross-reactivity observed among peanut and tree nut allergens. This structurally related cross-reactivity seems irrespective of the botanical origin of the allergens and thus demands that persons allergic to peanut avoid other three nuts to prevent possible allergic reactions. IaE-binding epitopes similar to those found in 11S globulin allergens do not apparently occur in other vicilin allergens with the cupin fold from peanut (Ara h 1) or tree nuts (Jug r 2 of walnut, Cor a I of hazel nut, Ana o 3 of cashew nut). (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：3243 / 3255

页数：13

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