Spread of Streptococcus pneumoniae Serotype 8-ST63 Multidrug-Resistant Recombinant Clone, Spain

被引：34

作者：

Ardanuy, Carmen ^{[1
,2
]}

de La Campa, Adela G. ^{[2
,3
,4
]}

Garcia, Ernesto ^{[2
,4
]}

Fenoll, Asuncion ^{[2
,3
]}

Calatayud, Laura ^{[1
,2
]}

Cercenado, Emilia ^{[2
,5
]}

Perez-Trallero, Emilio ^{[2
,6
]}

Bouza, Emilio ^{[2
,5
]}

Linares, Josefina ^{[1
,2
]}

机构：

[1] Univ Barcelona, Hosp Univ Bellvitge, Fundacio Privada, Inst Invest Biomed Bellvitge, Barcelona, Spain

[2] Ctr Invest Biomed Red Enfermedades Resp, Madrid, Spain

[3] Inst Salud Carlos II, Madrid, Spain

[4] Consejo Super Cient, Madrid, Spain

[5] Univ Complutense, Hosp Gregorio Maranon, E-28040 Madrid, Spain

[6] Hosp Univ Donostia, Donostia San Sebastian, Spain

来源：

EMERGING INFECTIOUS DISEASES | 2014年 / 20卷 / 11期

基金：

英国惠康基金;

关键词：

BINDING PROTEIN GENES; UNITED-STATES; ANTIMICROBIAL RESISTANCE; INVASIVE PNEUMOCOCCI; CLINICAL ISOLATE; FLUOROQUINOLONE; SEQUENCE; DISEASE; SUSCEPTIBILITY; EPIDEMIOLOGY;

D O I：

10.3201/eid2011.131215

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Since 2004, a total of 131 isolates of Streptococcus pneumoniae multidrug-resistant invasive serotype 8 have been detected in Spain. These isolates showed resistance to erythromycin, clindamycin, tetracycline, and ciprofloxacin. All isolates were obtained from adult patients and shared a common genotype (sequence type [ST]63; penicillin-binding protein 1a [pbp1a], pbp2b, and pbp2x gene profiles; ermB and tetM genes; and a ParC-S79F change). Sixty-eight isolates that required a ciprofloxacin MIC >= 16 mu g/mL had additional gyrA gene changes. Serotype 8-ST63 pbp2x sequences were identical with those of antimicrobial drug-susceptible serotype 8-ST53 isolates. Serotype 8-5T63 pbp2b sequences were identical with those of the multidrug-resistant Sweden 15A-ST63 clone. Recombination between the capsular locus and flanking regions of an ST53 isolate (donor) and an ST63 pneumococcus (recipient) generated the novel 15A-ST63 clone. One recombination point was upstream of pbp2x and another was within pbp1a. A serotype 8-ST63 clone was identified as a cause of invaeive disease in Spain.

引用

页码：1848 / 1856

页数：9

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