Lysosome-related organelles: a view from immunity and pigmentation

被引：46

作者：

Raposo, GA ^{[1
]}

Fevrier, B

Stoorvogel, W

Marks, MS

机构：

[1] Inst Curie, CNRS, UMR 144, F-75005 Paris, France

[2] Univ Utrecht, Med Ctr, Dept Cell Biol, NL-3585 CX Utrecht, Netherlands

[3] Biomembrane Inst, NL-3585 CX Utrecht, Netherlands

[4] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

CELL STRUCTURE AND FUNCTION | 2002年 / 27卷 / 06期

关键词：

MHC class II compartments; exosomes; melanosomes; lysosomes; multivesicular bodies;

D O I：

10.1247/csf.27.443

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lysosomes are ubiquitous organelles that carry out essential household functions. Certain cell types, however, contain lysosome-related organelles with specialized functions. Their specialized functions are usually reflected by specific morphological and compositional features. A number of diseases that develop due to genetic mutations, pathogen exposure or cell transformation are characterized by dysfunctional lysosomes and/or lysosome-related organelles. In this review we highlight adaptations and malfunction of the endosomal/lysosomal system in normal and pathological situations with special focus on MHC class 11 compartments in antigen presenting cells and melanosomes in pigment cells.

引用

页码：443 / 456

页数：14

共 131 条

[51] Major histocompatibility complex class II compartments in human and mouse B lymphoblasts represent conventional endocytic compartments [J].