The rate of poleward chromosome motion is attenuated in Drosophila zw10 and rod mutants

被引：109

作者：

Savoian, MS

Goldberg, ML

Rieder, CL ^{[1
]}

机构：

[1] New York State Dept Hlth, Wadsworth Ctr, Div Mol Med, Albany, NY 12201 USA

[2] SUNY Albany, Dept Biomed Sci, Albany, NY 12222 USA

[3] Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA

来源：

NATURE CELL BIOLOGY | 2000年 / 2卷 / 12期

关键词：

D O I：

10.1038/35046605

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Here we show that the rate of poleward chromosome motion in zw10-null mutants is greatly attenuated throughout the division process, and that chromosome disjunction at anaphase is highly asynchronous. Our results show that ZW10 protein, together with Rod, is involved in production and/or regulation of the force reponsible for poleward chromosome motion.

引用

页码：948 / 952

页数：5

共 21 条

[1]

BAJER AS, 1972, INT REV CYTOL S, V3, P1

[2] KINETOCHORE MICROTUBULES AND CHROMOSOME MOVEMENT DURING PROMETAPHASE IN DROSOPHILA-MELANOGASTER SPERMATOCYTES STUDIED IN LIFE AND WITH THE ELECTRON-MICROSCOPE [J].