Primate lentiviruses are differentially inhibited by interferon-induced transmembrane proteins

被引：34

作者：

Qian, Jin ^{[1
,2
]}

Le Duff, Yann ^{[1
]}

Wang, Yimeng ^{[1
,2
]}

Pan, Qinghua ^{[1
]}

Ding, Shilei ^{[1
,3
]}

Zheng, Yi-Min ^{[4
]}

Liu, Shan-Lu ^{[4
]}

Liang, Chen ^{[1
,2
,3
]}

机构：

[1] Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada

[2] McGill Univ, Dept Med, Montreal, PQ H3A 2B4, Canada

[3] McGill Univ, Dept Microbiol & Immunol, Montreal, PQ H3A 2B4, Canada

[4] Univ Missouri, Bond Life Sci Ctr, Sch Med, Dept Mol Microbiol & Immunol, Columbia, MO 65211 USA

来源：

VIROLOGY | 2015年 / 474卷

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

HIV; SIV; IFITM; Virus entry; WEST NILE VIRUS; IFITM PROTEINS; INFLUENZA-VIRUS; DENGUE VIRUS; INFECTION; UBIQUITINATION; MECHANISMS; RESISTANCE; RESTRICTS; EVOLUTION;

D O I：

10.1016/j.virol.2014.10.015

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Interferon-induced transmembrane (IFITM) proteins inhibit the entry of a large number of viruses. Not surprisingly, many viruses are refractory to this inhibition. In this study, we report that different strains of HIV and SIV are inhibited by human IFITM proteins to various degrees, with SW of African green monkeys (SIVAGM) being mostly restricted by human IFITM2. Interestingly, SIVAGM is as much inhibited by human IFITM2 as by IFITM3 of its own host African green monkeys. Our data further demonstrate that the entry of SIVAGM is impaired by human IFITM2 and that this inhibition is overcome by the cholesterol-binding compound amphotericin B that also overcomes IFITM inhibition of influenza A viruses. These results suggest that IFITM proteins exploit similar mechanisms to inhibit the entry of both pH-independent primate lentiviruses and the pH-dependent influenza A viruses. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：10 / 18

页数：9

共 34 条

[1] The Antiviral Effector IFITM3 Disrupts Intracellular Cholesterol Homeostasis to Block Viral Entry [J].

Amini-Bavil-Olyaee, Samad ;

Choi, Youn Jung ;

Lee, Jun Han ;

Shi, Mude ;

Huang, I-Chueh ;

Farzan, Michael ;

Jung, Jae U. .

CELL HOST & MICROBE, 2013, 13 (04) :452-464

[2] Interferon-inducible Transmembrane Protein 3 (IFITM3) Restricts Reovirus Cell Entry [J].

Anafu, Amanda A. ;

Bowen, Christopher H. ;

Chin, Christopher R. ;

Brass, Abraham L. ;

Holm, Geoffrey H. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (24) :17261-17271

[3] Interferon-induced Transmembrane Protein 3 Is a Type II Transmembrane Protein [J].

Bailey, Charles C. ;

Kondur, Hema R. ;

Huang, I-Chueh ;

Farzan, Michael .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (45) :32184-32193

[4] Ifitm3 Limits the Severity of Acute Influenza in Mice [J].

Bailey, Charles C. ;

Huang, I-Chueh ;

Kam, Christina ;

Farzan, Michael .

PLOS PATHOGENS, 2012, 8 (09)

[5] The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus [J].

Brass, Abraham L. ;

Huang, I-Chueh ;

Benita, Yair ;

John, Sinu P. ;

Krishnan, Manoj N. ;

Feeley, Eric M. ;

Ryan, Bethany J. ;

Weyer, Jessica L. ;

van der Weyden, Louise ;

Fikrig, Erol ;

Adams, David J. ;

Xavier, Ramnik J. ;

Farzan, Michael ;

Elledge, Stephen J. .

CELL, 2009, 139 (07) :1243-1254

[6] Phosphorylation of the Antiviral Protein Interferon-inducible Transmembrane Protein 3 ( IFITM3) Dually Regulates Its Endocytosis and Ubiquitination [J].

Chesarino, Nicholas M. ;

McMichael, Temet M. ;

Hach, Jocelyn C. ;

Yount, Jacob S. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (17) :11986-11992

[7] IFITM3 Restricts Influenza A Virus Entry by Blocking the Formation of Fusion Pores following Virus-Endosome Hemifusion [J].

Desai, Tanay M. ;

Marin, Mariana ;

Chin, Christopher R. ;

Savidis, George ;

Brass, Abraham L. ;

Melikyan, Gregory B. .

PLOS PATHOGENS, 2014, 10 (04)

[8] The broad-spectrum antiviral functions of IFIT and IFITM proteins [J].

Diamond, Michael S. ;

Farzan, Michael .

NATURE REVIEWS IMMUNOLOGY, 2013, 13 (01) :46-57

[9]

Earp LJ, 2005, CURR TOP MICROBIOL, V285, P25

[10] IFITM3 restricts the morbidity and mortality associated with influenza [J].

Everitt, Aaron R. ;

Clare, Simon ;

Pertel, Thomas ;

John, Sinu P. ;

Wash, Rachael S. ;

Smith, Sarah E. ;

Chin, Christopher R. ;

Feeley, Eric M. ;

Sims, Jennifer S. ;

Adams, David J. ;

Wise, Helen M. ;

Kane, Leanne ;

Goulding, David ;

Digard, Paul ;

Anttila, Verneri ;

Baillie, J. Kenneth ;

Walsh, Tim S. ;

Hume, David A. ;

Palotie, Aarno ;

Xue, Yali ;

Colonna, Vincenza ;

Tyler-Smith, Chris ;

Dunning, Jake ;

Gordon, Stephen B. ;

Smyth, Rosalind L. ;

Openshaw, Peter J. ;

Dougan, Gordon ;

Brass, Abraham L. ;

Kellam, Paul .

NATURE, 2012, 484 (7395) :519-U146

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