The broad-spectrum antiviral functions of IFIT and IFITM proteins

被引：673

作者：

Diamond, Michael S. ^{[1
,2
,3
]}

Farzan, Michael ^{[4
,5
]}

机构：

[1] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

[4] Harvard Univ, New England Primate Res Ctr, Sch Med, Southborough, MA 01772 USA

[5] Harvard Univ, Dept Microbiol & Immunol, Sch Med, Southborough, MA 01772 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2013年 / 13卷 / 01期

基金：

美国国家卫生研究院;

关键词：

INTERFERON-STIMULATED GENES; INDUCIBLE TRANSMEMBRANE PROTEINS; VIRUS-RNA REPLICATION; DOUBLE-STRANDED-RNA; WEST NILE VIRUS; MESSENGER-RNA; TRANSLATION INITIATION; S-PALMITOYLATION; DNA-REPLICATION; VIRAL-INFECTION;

D O I：

10.1038/nri3344

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Over the past few years, several groups have identified new genes that are transcriptionally induced downstream of type I interferon (IFN) signalling and that inhibit infection by individual or multiple families of viruses. Among these IFN-stimulated genes with antiviral activity are two genetically and functionally distinct families - the IFN-induced protein with tetratricopeptide repeats (IFIT) family and the IFN-induced transmembrane protein (IFITM) family. This Review focuses on recent advances in identifying the unique mechanisms of action of IFIT and IFITM proteins, which explain their broad-spectrum activity against the replication, spread and pathogenesis of a range of human viruses.

引用

页码：46 / 57

页数：12

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