Theory of mind ability in the behavioural variant of frontotemporal dementia: An analysis of the neural, cognitive, and social levels

被引:144
作者
Adenzato, Mauro [1 ,2 ]
Cavallo, Marco [1 ,3 ]
Enrici, Ivan [1 ]
机构
[1] Univ Turin, Dept Psychol, Ctr Cognit Sci, I-10123 Turin, Italy
[2] NIT, I-10125 Turin, Italy
[3] Amedeo Avogadro Univ Eastern Piedmont, Dept Med Sci, I-28100 Novara, Italy
关键词
Executive functions; Medial frontal cortex; Neuropsychiatric disorders; Social cognition; Social cognitive neuroscience; SPECIAL TOPIC PAPERS; FRONTAL VARIANT; SEMANTIC DEMENTIA; ASPERGER-SYNDROME; LOBAR DEGENERATION; ALZHEIMERS-DISEASE; DECISION-MAKING; MENTAL STATES; DEFAULT MODE; BASE-LINE;
D O I
10.1016/j.neuropsychologia.2009.08.001
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
010107 [宗教学]; 030301 [社会学]; 070906 [古生物学及地层学(含古人类学)];
摘要
The paper reviews convergent evidence on the ability to attribute mental states to one's self and to others (i.e., theory of mind, ToM) in patients affected by the behavioural variant of frontotemporal dementia (bv-FTD). This disease represents a particular challenge for researchers and clinicians, due to its insidious onset and ambiguous clinical features, which frequently render difficult a precise and timely diagnosis. The paper proposes a way to shed new light on the hypothesis that the neuropsychiatric profile of individuals with bv-FTD can be at least partially explained by a deficit in ToM ability. We examined both neuroimaging data on the neural correlates of ToM ability in healthy participants and studies investigating the progressive cerebral atrophy in patients with bv-FTD. Our findings suggest a link between the progressive degeneration of the anterior regions of medial frontal structures characterising the early stages of the bv-FTD and the ToM deficit these patients show. They also suggest the importance of using ToM tests during the diagnostic process of bv-FTD. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:2 / 12
页数:11
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