Rett syndrome and other autism spectrum disorders-brain diseases of immune malfunction?

被引：33

作者：

Derecki, N. C. ^{[1
,2
]}

Privman, E. ^{[1
,3
]}

Kipnis, J. ^{[1
,2
,3
]}

机构：

[1] Univ Virginia, Dept Neurosci, Charlottesville, VA 22903 USA

[2] Univ Virginia, Grad Program Neurosci, Charlottesville, VA USA

[3] Univ Virginia, Med Scientist Training Program, Charlottesville, VA USA

来源：

MOLECULAR PSYCHIATRY | 2010年 / 15卷 / 04期

关键词：

Rett syndrome; neuroimmunology; T cells; immune system; neurodevelopment; protective immunity; CENTRAL-NERVOUS-SYSTEM; REGULATORY T-CELLS; CLASS-I MHC; GENE-EXPRESSION; MOUSE MODEL; IFN-GAMMA; GLATIRAMER ACETATE; DENDRITIC CELLS; CHOROID-PLEXUS; COPOLYMER;

D O I：

10.1038/mp.2010.21

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neuroimmunology was once referred to in terms of its pathological connotation only and was generally understood as covering the deleterious involvement of the immune system in various diseases and disorders of the central nervous system (CNS). However, our conception of the function of the immune system in the structure, function, and plasticity of the CNS has undergone a sea change after relevant discoveries over the past two decades, and continues to be challenged by more recent studies of neurodevelopment and cognition. This review summarizes the recent advances in understanding of immune-system participation in the development and functioning of the CNS under physiological conditions. Considering as an example Rett syndrome a devastating neurodevelopmental disease, we offer a hypothesis that might help to explain the part played by immune cells in its etiology, and hence suggests that the immune system might be a feasible therapeutic target for alleviation of some of the symptoms of this and other autism spectrum disorders. Molecular Psychiatry (2010) 15, 355-363; doi: 10.1038/mp.2010.21; published online 23 February 2010

引用

页码：355 / 363

页数：9

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