PMR1/SPCA Ca2+ pumps and the role of the Golgi apparatus as a Ca2+ store

被引：88

作者：

Wuytack, F ^{[1
]}

Raeymaekers, L ^{[1
]}

Missiaen, L ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Fysiol Lab, B-3000 Louvain, Belgium

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2003年 / 446卷 / 02期

关键词：

Ca2+ oscillations; Golgi apparatus; manganese; PMR1; SPCA;

D O I：

10.1007/s00424-003-1011-5

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Besides the well-known sarco/endoplasmic-reticulum Ca2+-transport ATPases (SERCA), animal cells contain a much less characterized P-type Ca2+-transport ATPase: the PMR1/SPCA Ca2+/Mn2+-transport ATPase. SPCA is mainly targeted to the Golgi apparatus. Phylogenetic analysis indicates that it might be more closely related to a putative ancestral Ca2+ pump than SERCA. SPCA supplies the Golgi apparatus, and possibly other more distal compartments of the secretory pathway, with the Ca2+ and Mn2+ necessary for the production and processing of secretory proteins. In the lactating mammary gland, SPCA appears to be the primary pump responsible for supplementing the milk with high (60-100 mM) Ca2+. It could also play a role in detoxification of cells overloaded with Mn2+. Mutations in the human gene encoding the SPCA pump (ATP2C1) result in Hailey-Hailey disease, a keratinocyte disorder characterized by incomplete cell adhesion. Recent observations show that the Golgi apparatus can function as a Ca2+ store, which can be involved in setting up cytosolic Ca2+ oscillations.

引用

页码：148 / 153

页数：6

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