Rapid separation of basic drugs by nonaqueous capillary electrophoresis

被引:26
作者
Cherkaoui, S [1 ]
Geiser, L [1 ]
Veuthey, JL [1 ]
机构
[1] Univ Geneva, Lab Pharmaceut Analyt Chem, CH-1211 Geneva 4, Switzerland
关键词
nonaqueous capillary electrophoresis; rapid separation; pharmaceuticals; organic solvents;
D O I
10.1007/BF02535710
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Nonaqueous capillary electrophoresis (NACE) has been used to achieve rapid separations of basic drugs. A high electric field was obtained by using short capillaries, Baseline separations of basic drugs, including amphetamines, tropane alkaloids and local anesthetics, were achieved in I min by selection of the appropriate organic solvent and electrolyte composition. Thus, high-throughput analyses can be performed. Peak efficiency up to 9154 theoretical plates s(-1) was achieved in a separation performed at 923Vcm(-1). No discernible loss in resolution was observed when a conventional capillary (64.5cm) was replaced by a short (32.5cm) capillary.
引用
收藏
页码:403 / 407
页数:5
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