Elucidation of the neurobiology of depression: insights from a novel genetic animal model

被引：141

作者：

Yadid, G ^{[1
]}

Nakash, R ^{[1
]}

Deri, I ^{[1
]}

Tamer, G ^{[1
]}

Kinor, N ^{[1
]}

Gispan, I ^{[1
]}

Zangen, A ^{[1
]}

机构：

[1] Bar Ilan Univ, Fac Life Sci, Neuropharmacol Sect, IL-52900 Ramat Gan, Israel

来源：

PROGRESS IN NEUROBIOLOGY | 2000年 / 62卷 / 04期

关键词：

D O I：

10.1016/S0301-0082(00)00018-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Development of drugs for the effective treatment of depressive disorders requires elucidation of factors that are critical for clinically antidepressant effects. During the past 4 years, we have studied in situ neurochemical alterations in the brain that may underlie depressive behavior. This was achieved using the genetically-selected Flinders Sensitive Line (FSL) of rats (a unique animal model of depression), before and after chronic antidepressant treatment. This line of rats exhibits behavioral features characteristic of depression, and responds to chronic, but not acute, antidepressant treatments. This review summarizes our findings concerning the local neuro-dynamics in the brain during manifestation of depressive behavior and effective antidepressant treatment in this animal model of depression. Understanding the abnormalities manifested in neurochemical pathways during depressive disorders and the dynamic effects of these abnormalities on the onset of action and efficacy of pharmacological treatments are crucial for the development of effective antidepresssant drugs and therapeutic strategies. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：353 / 378

页数：26

共 271 条

[41]

Briner K, 1998, CURR PHARM DESIGN, V4, P291

[42]

BROWN R, 1985, AM J PSYCHIAT, V142, P811

[43]

Brown R S, 1990, Anesth Prog, V37, P223

[44]

Burke Michael J., 1995, P1053

[45] SPATIAL WORKING AND REFERENCE MEMORY IN RATS BRED FOR AUTONOMIC SENSITIVITY TO CHOLINERGIC STIMULATION - ACQUISITION, ACCURACY, SPEED, AND EFFECTS OF CHOLINERGIC DRUGS [J].

BUSHNELL, PJ ;

LEVIN, ED ;

OVERSTREET, DH .

NEUROBIOLOGY OF LEARNING AND MEMORY, 1995, 63 (02) :116-132

[46] CENTRAL AND PERIPHERAL 5-HT UPTAKE IN RATS TREATED CHRONICALLY WITH FEMOXETINE, PAROXETINE, AND CHLORIMIPRAMINE [J].

BUUSLASSEN, J ;

LUND, J ;

SONDERGAARD, I .

PSYCHOPHARMACOLOGY, 1980, 68 (03) :229-233

[47] THE EFFECTS OF SINGLE AND REPEATED ANORECTIC DOSES OF 5-HYDROXYTRYPTAMINE UPTAKE INHIBITORS ON INDOLE LEVELS IN RAT-BRAIN [J].

CACCIA, S ;

ANELLI, M ;

CODEGONI, AM ;

FRACASSO, C ;

GARATTINI, S .

BRITISH JOURNAL OF PHARMACOLOGY, 1993, 110 (01) :355-359

[48] NEW MODEL FOR THE DETECTION OF ANTIDEPRESSANT DRUGS - OLFACTORY BULBECTOMY IN THE RAT COMPARED WITH EXISTING MODELS [J].

CAIRNCROSS, KD ;

COX, B ;

FORSTER, C ;

WREN, AF .

JOURNAL OF PHARMACOLOGICAL METHODS, 1978, 1 (02) :131-143

[49] OLFACTORY PROJECTION SYSTEMS, DRUGS AND BEHAVIOR - REVIEW [J].

CAIRNCROSS, KD ;

COX, B ;

FORSTER, C ;

WREN, AF .

PSYCHONEUROENDOCRINOLOGY, 1979, 4 (03) :253-272

[50] EFFECTS OF OLFACTORY BULBECTOMY AND DOMICILE ON STRESS-INDUCED CORTICOSTERONE RELEASE IN RAT [J].

CAIRNCROSS, KD ;

WREN, A ;

COX, B ;

SCHNIEDEN, H .

PHYSIOLOGY & BEHAVIOR, 1977, 19 (04) :485-487

← 1 2 3 4 5 6 7 8 9 10 →