TonB-dependent energy transduction between outer and cytoplasmic membranes

被引：130

作者：

Postle, Kathleen ^{[1
]}

Larsen, Ray A.

机构：

[1] Penn State Univ, Dept Biochem & Mol Biol, Althouse Lab 301, University Pk, PA 16802 USA

[2] Bowling Green State Univ, Dept Biol Sci, Bowling Green, OH 43402 USA

来源：

BIOMETALS | 2007年 / 20卷 / 3-4期

关键词：

TonB; outer membrane; iron transport; B-group colicins; crystal and NMR structures;

D O I：

10.1007/s10534-006-9071-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The TonB system of Escherichia coli (and most other Gram-negative bacteria) is distinguished by its importance to iron acquisition, its contribution to bacterial pathogenesis, and a unique and mysterious mechanism of action. This system somehow gathers the potential energy of the cytoplasmic membrane (CM) proton gradient and delivers it to active transporters in the outer membrane (OM). Our understanding of this system is confounded by the challenge of reconciling often contradictory in vivo and in vitro studies that are presented in this review.

引用

页码：453 / 465

页数：13

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