Current concepts: An HIV vaccine - Evolving concepts

被引:193
作者
Johnston, Margaret I.
Fauci, Anthony S.
机构
[1] NIAID, Off Director, Bethesda, MD 20892 USA
[2] NIAID, Div AIDS, Bethesda, MD 20892 USA
关键词
D O I
10.1056/NEJMra066267
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:2073 / 2081
页数:9
相关论文
共 56 条
  • [1] The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes
    Alam, S. Munir
    McAdams, Mildred
    Boren, David
    Rak, Michael
    Scearce, Richard M.
    Gao, Feng
    Camacho, Zenaido T.
    Gewirth, Daniel
    Kelsoe, Garnett
    Chen, Pojen
    Haynes, Barton F.
    [J]. JOURNAL OF IMMUNOLOGY, 2007, 178 (07) : 4424 - 4435
  • [2] Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine
    Amara, RR
    Villinger, F
    Altman, JD
    Lydy, SL
    O'Neil, SP
    Staprans, SI
    Montefiori, DC
    Xu, Y
    Herndon, JG
    Wyatt, LS
    Candido, MA
    Kozyr, NL
    Earl, PL
    Smith, JM
    Ma, HL
    Grimm, BD
    Hulsey, ML
    Miller, J
    McClure, HM
    McNicholl, JM
    Moss, B
    Robinson, HL
    [J]. SCIENCE, 2001, 292 (5514) : 69 - 74
  • [3] Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes
    Barouch, DH
    Kunstman, J
    Kuroda, MJ
    Schmitz, JE
    Santra, S
    Peyerl, FW
    Krivulka, GR
    Beaudry, K
    Lifton, MA
    Gorgone, DA
    Montefiori, DC
    Lewis, MG
    Wolinsky, SM
    Letvin, NL
    [J]. NATURE, 2002, 415 (6869) : 335 - 339
  • [4] Blower Sally M., 2005, Current Drug Targets - Infectious Disorders, V5, P179, DOI 10.2174/1568005054201616
  • [5] CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract
    Brenchley, JM
    Schacker, TW
    Ruff, LE
    Price, DA
    Taylor, JH
    Beilman, GJ
    Nguyen, PL
    Khoruts, A
    Larson, M
    Haase, AT
    Douek, DC
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (06) : 749 - 759
  • [6] HIV vaccine design and the neutralizing antibody problem
    Burton, DR
    Desrosiers, RC
    Doms, RW
    Koff, WC
    Kwong, PD
    Moore, JP
    Nabel, GJ
    Sodroski, J
    Wilson, IA
    Wyatt, RT
    [J]. NATURE IMMUNOLOGY, 2004, 5 (03) : 233 - 236
  • [7] Viral burden in genital secretions determines male-to-female sexual transmission of HIV-1: a probabilistic empiric model
    Chakraborty, H
    Sen, PK
    Helms, RW
    Vernazza, PL
    Fiscus, SA
    Eron, JJ
    Patterson, BK
    Coombs, RW
    Krieger, JN
    Cohen, MS
    [J]. AIDS, 2001, 15 (05) : 621 - 627
  • [8] Structure of an unliganded simian immunodeficiency virus gp120 core
    Chen, B
    Vogan, EM
    Gong, HY
    Skehel, JJ
    Wiley, DC
    Harrison, SC
    [J]. NATURE, 2005, 433 (7028) : 834 - 841
  • [9] Plasma viral load and CD4 lymphocytes predict HIV-associated dementia and sensory neuropathy
    Childs, EA
    Lyles, RH
    Selnes, OA
    Chen, B
    Miller, EN
    Cohen, BA
    Becker, JT
    Mellors, J
    McArthur, JC
    [J]. NEUROLOGY, 1999, 52 (03) : 607 - 613
  • [10] HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir
    Chun, TW
    Nickle, DC
    Justement, JS
    Large, D
    Semerjian, A
    Curlin, ME
    O'Shea, MA
    Hallahan, CW
    Daucher, M
    Ward, DJ
    Moir, S
    Mullins, JI
    Kovacs, C
    Fauci, AS
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (11) : 3250 - 3255