Design strategies to improve soluble macromolecular delivery constructs

被引：87

作者：

Christie, RJ ^{[1
]}

Grainger, DW ^{[1
]}

机构：

[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2003年 / 55卷 / 03期

关键词：

subcellular drug delivery; membrane destabilization; nuclear localization signal; drug targeting; polymer-drug conjugate;

D O I：

10.1016/S0169-409X(02)00229-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Macromolecular therapeutics provide numerous benefits for the delivery of cytotoxic or poorly soluble drugs in vivo. However, these constructs often encounter barriers for drug delivery on both the systemic and subcellular level. Many soluble polymer carriers have been designed to surmount specific physiological barriers individually, but less work has been dedicated to designing an all-encompassing construct that addresses multiple therapeutic barriers at once. Incorporation of multiple agents already individually known to increase effectiveness into one carrier could further improve current drug delivery technology. Recent developments in subcellular delivery of therapeutic agents in soluble macromolecular carriers are discussed in the context of the future possibility for the design of an all-encompassing soluble multi-functional drug delivery vehicle. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：421 / 437

页数：17

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