Huganpian, a traditional chinese medicine, inhibits liver cancer growth in vitro and in vivo by inducing autophagy and cell cycle arrest

被引：31

作者：

Gao, Xue ^{[1
]}

Wang, Yuyang ^{[2
]}

Li, Yuxin ^{[1
]}

Wang, Yansong ^{[1
]}

Yan, Miaomiao ^{[1
]}

Sun, Hongliu ^{[1
]}

Chen Shayan ^{[3
,4
]}

Xiaohong Pan ^{[1
]}

机构：

[1] Binzhou Med Univ, Dept Pharmaceut Sci, Yantai 264003, Peoples R China

[2] Jining Med Univ, Inst Forens Med & Lab Med, Jining 272067, Peoples R China

[3] Tianjin Med Univ, NanKai Hosp, Dept Lab Sci, Tianjin 300100, Peoples R China

[4] Tianjin Med Univ, NanKai Hosp, Tianjin Key Lab Acute Abdomen Dis Associated Orga, Tianjin 300100, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2019年 / 120卷

基金：

中国国家自然科学基金;

关键词：

Huganpian; Liver cancer; Tumor growth; Autophagy; Cell cycle; HEPATOCELLULAR-CARCINOMA; DECOCTION; 5-FLUOROURACIL; INFLAMMATION; RESISTANCE; APOPTOSIS; ANTITUMOR;

D O I：

10.1016/j.biopha.2019.109469

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Huganpian (HGP), a traditional chinese medicine composed of 6 herbs, possesses excellent therapeutic effects in clinical application. In this study, we aimed to elucidate the anti-tumor activity and the underlying mechanisms of HGP in liver cancer. The results of this study indicated that HGP effectively inhibited liver cancer growth in vitro and in vivo in a dose-dependent manner. Mechanistically, HGP exerted its anti-tumor effects by triggering autophagy with increased LC3. and beclin1 levels and arrested the cell cycle on G0-G1 phase by downregulating the expressions of cyclin-dependent kinase 2 (CDK2), cyclin-dependent kinase 4 (CDK4) and cyclinE1 in vitro and in vivo. Meanwhile, HGP did not induce apoptosis significantly. Importantly, we also confirmed that there were fewer side effects of HGP on immune system. Taken together, our findings suggest for the first time that HGP may become a promising drug or adjuvant drug with a lower toxicity for liver cancer treatment in the future.

引用

页数：7

共 38 条

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