Rituximab stabilizes multifocal motor neuropathy increasingly less responsive to IVIg

被引：66

作者：

Rüegg, SJ ^{[1
]}

Fuhr, P ^{[1
]}

Steck, AJ ^{[1
]}

机构：

[1] Univ Basel Hosp, Dept Neurol, CH-4031 Basel, Switzerland

来源：

NEUROLOGY | 2004年 / 63卷 / 11期

关键词：

D O I：

10.1212/01.WNL.0000145706.04340.25

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors report a patient with anti-GM(1) antibody-negative multifocal motor neuropathy (MMN) who was increasingly less responsive to IV immunoglobulins (IVIgs). Five yearly courses of the monoclonal anti-CD20 antibody rituximab were well tolerated and extended the interval of IVIg administration from 7 to 12 days ( corresponding to 42% reduction of IVIg) during this period. Rituximab may be a benefit for patients with MMN.

引用

页码：2178 / 2179

页数：2

共 10 条

[1]

Hughes P R, 2001, Neuromuscul Disord, V11, P309, DOI 10.1016/S0960-8966(00)00191-7

[2]

IMAPATHI T, 2002, COCHRANE DATABASE SY, V2

[3] Intravenous immunoglobulin therapy in multifocal motor neuropathy -: A double-blind, placebo-controlled study [J].

Léger, JM ;

Chassande, B ;

Musset, L ;

Meininger, V ;

Bouche, P ;

Baumann, N .

BRAIN, 2001, 124 :145-153

[4] Multifocal motor neuropathy [J].

Nobile-Orazio, E .

JOURNAL OF NEUROIMMUNOLOGY, 2001, 115 (1-2) :4-18

[5] Treatment of IgM antibody associated polyneuropathies using rituximab [J].

Pestronk, A ;

Florence, J ;

Miller, T ;

Choksi, R ;

Al-Lozi, MT ;

Levine, TD .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2003, 74 (04) :485-489

[6] Rituximab in the treatment of polyneuropathy associated with anti-MAG antibodies [J].

Renaud, S ;

Gregor, M ;

Fuhr, P ;

Lorenz, D ;

Deuschl, G ;

Gratwohl, A ;

Steck, AJ .

MUSCLE & NERVE, 2003, 27 (05) :611-615

[7] Chronic neuropathy with IgM antiganglioside antibodies:: Lack of long term response to rituximab [J].

Rojas-García, R ;

Gallardo, E ;

de Andrés, I ;

de Luna, N ;

Juarez, C ;

Sánchez, P ;

Illa, I .

NEUROLOGY, 2003, 61 (12) :1814-1816

[8] Rituximab (monoclonal anti-CD20 antibody): mechanisms of action and resistance [J].

Smith, MR .

ONCOGENE, 2003, 22 (47) :7359-7368

[9] How long is IVIg effective in multifocal motor neuropathy? [J].

Terenghi, F ;

Cappellari, A ;

Bersano, A ;

Carpo, M ;

Barbieri, S ;

Nobile-Orazio, E .

NEUROLOGY, 2004, 62 (04) :666-668

[10]

Voog E, 2003, NEW ENGL J MED, V348, P2691

← 1 →