Aspects of the early moments of interaction between tachyzoites of Toxoplasma gondii with neutrophils

被引：28

作者：

MacLaren, A ^{[1
]}

Attias, M ^{[1
]}

de Souza, W ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Lab Ultraestrut Celular Hertha Meyer, Inst Biofis Carlos Chagas Filho, BR-21941900 Rio De Janeiro, Brazil

来源：

VETERINARY PARASITOLOGY | 2004年 / 125卷 / 3-4期

关键词：

tachyzoite; filopodia; tyrosine kinase;

D O I：

10.1016/j.vetpar.2004.07.006

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The interaction of the tachyzoite stage of Toxoplasma gondii with neutrophils was investigated. Morphological aspects of the initial moments of interaction were analyzed by transmission and scanning electron microscopy, revealing at least three types of reaction from the leukocytes to the parasite: the projection of filopodia, formation of a tunnel-like projection involving the parasite, and invagination of the leukocyte surface at the point of entry. The influence on infectivity of tyrosine kinase, phosphokinase C and phosphatidylinositol 3 kinase cell signaling pathways were studied with the aid of drugs affecting these enzymes in these cells. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：301 / 312

页数：12

共 24 条

[1] Effect of protein kinase inhibitors on the growth, morphology, and infectivity of Leishmania promastigotes [J].