Highly enantioselective synthesis of a chiral 3-quinolylalkanol by an asymmetric autocatalytic reaction

被引：58

作者：

Shibata, T ^{[1
]}

Choji, K ^{[1
]}

Morioka, H ^{[1
]}

Hayase, T ^{[1
]}

Soai, K ^{[1
]}

机构：

[1] SCI UNIV TOKYO,FAC SCI,DEPT APPL CHEM,SHINJUKU KU,TOKYO 162,JAPAN

来源：

CHEMICAL COMMUNICATIONS | 1996年 / 06期

关键词：

D O I：

10.1039/cc9960000751

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A catalytic amount of a chiral zinc alkoxide of 2-methyl-1-(3-quinolyl)propan-1-ol catalyses the enantioselective alkylation of quinoline-3-carbaldehyde by diisopropylzine to afford 2-methyl-1-(3-quinolyl)propan-1-ol with the same configuration in high ee (up to 94%).

引用

页码：751 / 752

页数：2

共 24 条

[21]

SOAI K, 1995, YUKI GOSEI KAGAKU KY, V53, P138

[22] ASYMMETRIC-SYNTHESIS OF CHIRAL SECONDARY ALCOHOLS WITH ISOPROPYL SUBSTITUENTS BY THE CATALYTIC ENANTIOSELECTIVE ADDITION OF DIISOPROPYLZINC TO ALDEHYDES USING N,N-DIALKYLNOREPHEDRINES AS CHIRAL CATALYSTS [J].

SOAI, KS ;

HAYASE, T ;

TAKAI, K ;

SUGIYAMA, T .

JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (25) :7908-7909

[23] NITROGEN DONORS IN ORGANOMETALLIC CHEMISTRY AND HOMOGENEOUS CATALYSIS [J].

TOGNI, A ;

VENANZI, LM .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1994, 33 (05) :497-526

[24] ASYMMETRIC AUTO-CATALYSIS - FACTS AND FANCY [J].

WYNBERG, H .

JOURNAL OF MACROMOLECULAR SCIENCE-CHEMISTRY, 1989, A26 (08) :1033-1041

← 1 2 3 →