Fetal human neural progenitors can be the target for tumor transformation

被引：9

作者：

Wang, YJ ^{[1
]}

Bai, Y ^{[1
]}

Li, XX ^{[1
]}

Hu, QK ^{[1
]}

Lin, CS ^{[1
]}

Xiao, ZF ^{[1
]}

Liu, YN ^{[1
]}

Xu, JC ^{[1
]}

Shen, L ^{[1
]}

Li, LS ^{[1
]}

机构：

[1] Peking Univ, Hlth Sci Ctr, Stem Cell Res Ctr, Beijing 100083, Peoples R China

来源：

NEUROREPORT | 2004年 / 15卷 / 12期

关键词：

hNPCs; hTERT; mutation; neoplasia; transformation;

D O I：

10.1097/00001756-200408260-00015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The hypothesis that stem cells may seed cancer has emerged from the cancer stem cells concept. However, the experimental systems necessary to provide more direct evidence to support the hypothesis have been lacking. We have used fetal neural progenitor cells (hNPC) transduced with the telomerase hTERT gene to investigate the neoplastic potential of hNPCs. The hTERT-transduced line, hNPCs-G3 lost normal diploid karyotype, showed loss of contact inhibition, anchorage independence, and formed neuroblastoma-like tumours in all of 10 mice. These data suggest that hNPCs have the potential for neoplastic transformation. These data have implications for providing a novel tool to test the feasibility of new anticancer treatment strategies and raise the possibility of a risk for the use of hNPCs in cell transplantation.

引用

页码：1907 / 1912

页数：6