Influence of repetitive transcranial magnetic stimulation on psychomotor symptoms in major depression

被引：25

作者：

Hoeppner, Jacqueline ^{[1
]}

Padberg, Frank ^{[2
]}

Domes, Gregor ^{[3
]}

Zinke, Antonia ^{[1
]}

Herpertz, Sabine C. ^{[1
]}

Grossheinrich, Nicola ^{[2
]}

Herwig, Uwe ^{[4
]}

机构：

[1] Univ Rostock, Ctr Nervous Dis, Dept Psychiat & Psychotherapy, D-18147 Rostock, Germany

[2] Univ Munich, Dept Psychiat & Psychotherapy, D-80336 Munich, Germany

[3] Univ Zurich, Dept Psychol Clin Psychol & Psychobiol, CH-8050 Zurich, Switzerland

[4] Psychiat Univ Hosp Zurich, CH-8032 Zurich, Switzerland

来源：

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | 2010年 / 260卷 / 03期

关键词：

Repetitive transcranial magnetic stimulation; Major depression; Psychomotor agitation; Retardation; STRIATAL DOPAMINE RELEASE; GENDER-DIFFERENCES; SEX-DIFFERENCES; RETARDATION; ABNORMALITIES; AGITATION; CORTEX; RTMS; TWIN;

D O I：

10.1007/s00406-009-0039-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Psychomotor symptoms related to an impairment of the nigrostriatal dopaminergic system are frequent in major depression (MD). Repetitive transcranial magnetic stimulation (rTMS) has been discussed as a new treatment option for MD. In neurobiological terms, an influence of high-frequency rTMS on dopaminergic neurotransmission has previously been shown by several studies in animals and humans. Therefore, an improvement of psychomotor symptoms by rTMS could be assumed. The aim of this pilot study was to investigate the effect of high-frequency rTMS on psychomotor retardation and agitation in depressive patients. We investigated the effect of left prefrontal 10 Hz rTMS on psychomotor retardation and agitation in 30 patients with MD. Patients were randomly assigned to real or sham rTMS in addition to a newly initiated standardized antidepressant medication. We found a trend in the reduction of agitation (t(28) = 1.76, p = 0.09, two-tailed), but not in the reduction of retardation. Furthermore, no general additional antidepressant effect of rTMS was observed. Although there was no statistical significant influence of high-frequency rTMS on psychomotor symptoms in depressive patients, the results showed a trend in the reduction of psychomotor agitation in MD. This effect should be systematically investigated as the primary end point in further studies with larger sample sizes.

引用

页码：197 / 202

页数：6

共 25 条

[1] Gender differences in patients with Parkinson's disease treated with subthalamic deep brain stimulation [J].

Accolla, Ettore ;

Caputo, Elena ;

Cogiamanian, Filippo ;

Tamma, Filippo ;

Mrakic-Sposta, Simona ;

Marceglia, Sara ;

Egidi, Marcello ;

Rampini, Paolo ;

Locatelli, Marco ;

Priori, Alberto .

MOVEMENT DISORDERS, 2007, 22 (08) :1150-1156

[2] Does psychomotor agitation in major depressive episodes indicate bipolarity? [J].

Angst, Jules ;

Gamma, Alex ;

Benazzi, Franco ;

Ajdacic, Vladeta ;

Roessler, Wulf .

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 2009, 259 (01) :55-63

[3] Serotoninergics attenuate hyperlocomotor activity in rats. Potential new therapeutic strategy for hyperactivity [J].

Brus, R ;

Nowak, P ;

Szkilnik, R ;

Mikolajun, U ;

Kostrzewa, RM .

NEUROTOXICITY RESEARCH, 2004, 6 (04) :317-325

[4] Antidepressant effects of augmentative transcranial magnetic stimulation -: Randomised multicentre trial [J].

Herwig, U. ;

Fallgatter, A. J. ;

Hoeppner, J. ;

Eschweiler, G. W. ;

Kron, M. ;

Hajak, G. ;

Padberg, F. ;

Naderi-Heiden, A. ;

Abler, B. ;

Eichhammer, P. ;

Grossheinrich, N. ;

Hay, B. ;

Kammer, T. ;

Langguth, B. ;

Laske, C. ;

Plewnia, C. ;

Richter, M. M. ;

Schulz, M. ;

Unterecker, S. ;

Zinke, A. ;

Spitzer, M. ;

Schonfeldt-Lecuona, C. .

BRITISH JOURNAL OF PSYCHIATRY, 2007, 191 :441-448

[5] Substantia nigra hyperechogenicity in depressive subjects relates to motor asymmetry and impaired word fluency [J].

Hoeppner, Jacqueline ;

Prudente-Morrissey, Lara ;

Herpertz, Sabine Christiane ;

Benecke, Reiner ;

Walter, Uwe .

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 2009, 259 (02) :92-97

[6] Antidepressant efficacy of two different rTMS procedures -: High frequency over left versus low frequency over right prefrontal cortex compared with sham stimulation [J].

Höppner, J ;

Schulz, M ;

Irmisch, G ;

Mau, R ;

Schläfke, D ;

Richter, J .

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 2003, 253 (02) :103-109

[7] Effect of age, gender, menopausal status, and ovarian hormonal level on rTMS in treatment-resistant depression [J].

Huang, Chih-Chia ;

Wei, I-Hua ;

Chou, Yuan-Hwa ;

Su, Tung-Ping .

PSYCHONEUROENDOCRINOLOGY, 2008, 33 (06) :821-831

[8] Effects of acute repetitive transcranial magnetic stimulation on extracellular serotonin concentration in the rat prefrontal cortex [J].

Kanno, M ;

Matsumoto, M ;

Togashi, H ;

Yoshioka, M ;

Mano, Y .

JOURNAL OF PHARMACOLOGICAL SCIENCES, 2003, 93 (04) :451-457

[9] Repetitive transcranial magnetic stimulation increases the release of dopamine in the mesolimbic and mesostriatal system [J].

Keck, ME ;

Welt, T ;

Müller, MB ;

Erhardt, A ;

Ohl, F ;

Toschi, N ;

Holsboer, F ;

Sillaber, I .

NEUROPHARMACOLOGY, 2002, 43 (01) :101-109

[10] Gender differences in the symptoms of major depression in opposite-sex dizygotic twin pairs [J].

Khan, AA ;

Gardner, CO ;

Prescott, CA ;

Kendler, KS .

AMERICAN JOURNAL OF PSYCHIATRY, 2002, 159 (08) :1427-1429

← 1 2 3 →