New reagents for controlled release of nitric oxide. Structure-stability relationships

被引：53

作者：

Kato, M

Nishino, S

Ohno, M

Fukuyama, S

Kita, Y

Hirasawa, Y

Nakanishi, I

Takasugi, H

Sakane, K

机构：

[1] FUJISAWA PHARMACEUT CO LTD,ANALYT RES LABS,YODOGAWA KU,OSAKA 532,JAPAN

[2] FUJISAWA PHARMACEUT CO LTD,BASIC RES LABS,YODOGAWA KU,OSAKA 532,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 01期

关键词：

D O I：

10.1016/0960-894X(95)00547-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and structure-stability relationships of a series of novel FK409 derivatives (1, 2, and 3) are described. The rates of decomposition in aqueous solution (pH 8.0, 30 degrees C) were parallel with those of spontaneous NO release measured by ESR spectroscopy using carboxy-PTIO. The compounds can cover a wide range of NO releasing rates by appropriate modification of the molecule.

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页码：33 / 38

页数：6

相关论文

共 13 条

[1] ANTAGONISTIC ACTION OF IMIDAZOLINEOXYL N-OXIDES AGAINST ENDOTHELIUM-DERIVED RELAXING FACTOR .NO THROUGH A RADICAL REACTION [J].

AKAIKE, T ;

YOSHIDA, M ;

MIYAMOTO, Y ;

SATO, K ;

KOHNO, M ;

SASAMOTO, K ;

MIYAZAKI, K ;

UEDA, S ;

MAEDA, H .

BIOCHEMISTRY, 1993, 32 (03) :827-832

[2]

Az-Ma Toshiharu, 1994, Life Sciences, V54, P185

[3]

DECOUT JL, 1995, MED CHEM LETT, V5, P973

[4] A NEW NITRIC-OXIDE (NO) RELEASER - SPONTANEOUS NO RELEASE FROM FK409 [J].

FUKUYAMA, S ;

KITA, Y ;

HIRASAWA, Y ;

SATO, A ;

MOROKOSHI, N ;

KODA, S ;

YASUDA, T ;

OKA, S ;

SAKURAI, H .

FREE RADICAL RESEARCH, 1995, 23 (05) :443-452

[5] FK409, A NOVEL VASODILATOR ISOLATED FROM THE ACID-TREATED FERMENTATION BROTH OF STREPTOMYCES-GRISEOSPOREUS .1. TAXONOMY, FERMENTATION, ISOLATION, AND PHYSICOCHEMICAL AND BIOLOGICAL CHARACTERISTICS [J].

HINO, M ;

IWAMI, M ;

OKAMOTO, M ;

YOSHIDA, K ;

HARUTA, H ;

OKUHARA, M ;

HOSODA, J ;

KOHSAKA, M ;

AOKI, H ;

IMANAKA, H .

JOURNAL OF ANTIBIOTICS, 1989, 42 (11) :1578-1583

[6] ANTIPLATELET ACTIVITIES OF FK409, A NEW SPONTANEOUS NO RELEASER [J].

KITA, Y ;

HIRASAWA, Y ;

YOSHIDA, K ;

MAEDA, K .

BRITISH JOURNAL OF PHARMACOLOGY, 1994, 113 (02) :385-388

[7] ANTIANGINAL EFFECTS OF FK409, A NEW SPONTANEOUS NO RELEASER [J].

KITA, Y ;

OZAKI, R ;

SAKAI, S ;

SUGIMOTO, T ;

HIRASAWA, Y ;

OHTSUKA, M ;

SENOH, H ;

YOSHIDA, K ;

MAEDA, K .

BRITISH JOURNAL OF PHARMACOLOGY, 1994, 113 (04) :1137-1140

[8] SPONTANEOUS NITRIC-OXIDE RELEASE ACCOUNTS FOR THE POTENT PHARMACOLOGICAL ACTIONS OF FK409 [J].

KITA, Y ;

HIRASAWA, Y ;

MAEDA, K ;

NISHIO, M ;

YOSHIDA, K .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1994, 257 (1-2) :123-130

[9] CLOSE CORRELATION OF THE CARDIOPROTECTIVE EFFECT OF FK409, A SPONTANEOUS NO RELEASER, WITH AN INCREASE IN PLASMA CYCLIC-GMP LEVEL [J].

KITA, Y ;

SUGIMOTO, T ;

HIRASAWA, Y ;

YOSHIDA, K ;

MAEDA, K .

BRITISH JOURNAL OF PHARMACOLOGY, 1994, 113 (01) :5-6

[10] COMPLEXES OF NO WITH NUCLEOPHILES AS AGENTS FOR THE CONTROLLED BIOLOGICAL RELEASE OF NITRIC-OXIDE - VASORELAXANT EFFECTS [J].

MARAGOS, CM ;

MORLEY, D ;

WINK, DA ;

DUNAMS, TM ;

SAAVEDRA, JE ;

HOFFMAN, A ;

BOVE, AA ;

ISAAC, L ;

HRABIE, JA ;

KEEFER, LK .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (11) :3242-3247