An artificial base pair, mediated by hydrogen bonding and metal-ion binding

被引：107

作者：

Polonius, Fabian-Alexander ^{[1
]}

Mueller, Jens ^{[1
]}

机构：

[1] Univ Dortmund, Fachbereich Chem, D-44227 Dortmund, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 29期

关键词：

bioinorganic chemistry; DNA; Hoogsteen pairs; hydrogen bonds; nucleobases;

D O I：

10.1002/anie.200700315

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Silver service: Addition of silver(I) to an oligonucleotide comprising 1-deazaadenine and thymine nucleobases leads to the formation of a Hoogsteen-type double helix with specific binding of one metal ion per base pair (see scheme). Each base pair is mediated by one hydrogen bond and by two coordination bonds. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5602 / 5604

页数：3

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